Clinical features and prognostic factors of brain metastasis from esophageal carcinoma

Akihiko Okamura, Hiroya Takeuchi, Hiroyuki Sako, Rieko Nakamura, Tsunehiro Takahashi, Norihito Wada, Hirofumi Kawakubo, Yoshiro Saikawa, Tai Omori, Soji Ozawa, Yuukou Kitagawa

研究成果: Article

2 引用 (Scopus)

抄録

Background: Brain metastasis from esophageal carcinoma is uncommon. The aims of this study were to assess the frequency of brain metastasis from esophageal carcinoma, describe treatment modalities and their outcomes, and determine predictors of survival. Methods: Between 2004 and 2012, 680 patients with esophageal carcinoma were registered at Keio University Hospital, Tokyo, Japan. Of these patients, 16 (2.3 %) were diagnosed with brain metastasis. We reviewed their medical records and performed statistical analyses. Results: The median survival after diagnosis of brain metastasis was 5.0 months (95 % CI 1.2-8.7 months). The only statistically significant baseline characteristic that predicted worse survival from brain metastasis was the onset form of brain metastasis (p = 0.01). At the onset of brain metastasis, the median survival from brain metastasis was 13.0 months (95 % CI 0.0-31.0 months) in patients without extracranial metastasis and 2.0 months (95 % CI 0.0-4.3 months) in patients with extracranial metastasis (p = 0.01). Conclusions: Approximately 2 % patients with esophageal carcinoma were diagnosed with brain metastasis. The prognosis of brain metastasis is extremely poor, but long-term survival may be expected with intensive treatment for brain metastasis when the first metastatic site is the brain.

元の言語English
ページ(範囲)217-222
ページ数6
ジャーナルEsophagus
11
発行部数4
DOI
出版物ステータスPublished - 2014

Fingerprint

Neoplasm Metastasis
Carcinoma
Brain
Survival
Tokyo
Medical Records
Japan
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

これを引用

Clinical features and prognostic factors of brain metastasis from esophageal carcinoma. / Okamura, Akihiko; Takeuchi, Hiroya; Sako, Hiroyuki; Nakamura, Rieko; Takahashi, Tsunehiro; Wada, Norihito; Kawakubo, Hirofumi; Saikawa, Yoshiro; Omori, Tai; Ozawa, Soji; Kitagawa, Yuukou.

:: Esophagus, 巻 11, 番号 4, 2014, p. 217-222.

研究成果: Article

Okamura, Akihiko ; Takeuchi, Hiroya ; Sako, Hiroyuki ; Nakamura, Rieko ; Takahashi, Tsunehiro ; Wada, Norihito ; Kawakubo, Hirofumi ; Saikawa, Yoshiro ; Omori, Tai ; Ozawa, Soji ; Kitagawa, Yuukou. / Clinical features and prognostic factors of brain metastasis from esophageal carcinoma. :: Esophagus. 2014 ; 巻 11, 番号 4. pp. 217-222.
@article{3cb856bca4244983b9b99e97df5b9b5d,
title = "Clinical features and prognostic factors of brain metastasis from esophageal carcinoma",
abstract = "Background: Brain metastasis from esophageal carcinoma is uncommon. The aims of this study were to assess the frequency of brain metastasis from esophageal carcinoma, describe treatment modalities and their outcomes, and determine predictors of survival. Methods: Between 2004 and 2012, 680 patients with esophageal carcinoma were registered at Keio University Hospital, Tokyo, Japan. Of these patients, 16 (2.3 {\%}) were diagnosed with brain metastasis. We reviewed their medical records and performed statistical analyses. Results: The median survival after diagnosis of brain metastasis was 5.0 months (95 {\%} CI 1.2-8.7 months). The only statistically significant baseline characteristic that predicted worse survival from brain metastasis was the onset form of brain metastasis (p = 0.01). At the onset of brain metastasis, the median survival from brain metastasis was 13.0 months (95 {\%} CI 0.0-31.0 months) in patients without extracranial metastasis and 2.0 months (95 {\%} CI 0.0-4.3 months) in patients with extracranial metastasis (p = 0.01). Conclusions: Approximately 2 {\%} patients with esophageal carcinoma were diagnosed with brain metastasis. The prognosis of brain metastasis is extremely poor, but long-term survival may be expected with intensive treatment for brain metastasis when the first metastatic site is the brain.",
keywords = "Brain metastasis, Esophageal carcinoma",
author = "Akihiko Okamura and Hiroya Takeuchi and Hiroyuki Sako and Rieko Nakamura and Tsunehiro Takahashi and Norihito Wada and Hirofumi Kawakubo and Yoshiro Saikawa and Tai Omori and Soji Ozawa and Yuukou Kitagawa",
year = "2014",
doi = "10.1007/s10388-014-0434-8",
language = "English",
volume = "11",
pages = "217--222",
journal = "Esophagus",
issn = "1612-9059",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - Clinical features and prognostic factors of brain metastasis from esophageal carcinoma

AU - Okamura, Akihiko

AU - Takeuchi, Hiroya

AU - Sako, Hiroyuki

AU - Nakamura, Rieko

AU - Takahashi, Tsunehiro

AU - Wada, Norihito

AU - Kawakubo, Hirofumi

AU - Saikawa, Yoshiro

AU - Omori, Tai

AU - Ozawa, Soji

AU - Kitagawa, Yuukou

PY - 2014

Y1 - 2014

N2 - Background: Brain metastasis from esophageal carcinoma is uncommon. The aims of this study were to assess the frequency of brain metastasis from esophageal carcinoma, describe treatment modalities and their outcomes, and determine predictors of survival. Methods: Between 2004 and 2012, 680 patients with esophageal carcinoma were registered at Keio University Hospital, Tokyo, Japan. Of these patients, 16 (2.3 %) were diagnosed with brain metastasis. We reviewed their medical records and performed statistical analyses. Results: The median survival after diagnosis of brain metastasis was 5.0 months (95 % CI 1.2-8.7 months). The only statistically significant baseline characteristic that predicted worse survival from brain metastasis was the onset form of brain metastasis (p = 0.01). At the onset of brain metastasis, the median survival from brain metastasis was 13.0 months (95 % CI 0.0-31.0 months) in patients without extracranial metastasis and 2.0 months (95 % CI 0.0-4.3 months) in patients with extracranial metastasis (p = 0.01). Conclusions: Approximately 2 % patients with esophageal carcinoma were diagnosed with brain metastasis. The prognosis of brain metastasis is extremely poor, but long-term survival may be expected with intensive treatment for brain metastasis when the first metastatic site is the brain.

AB - Background: Brain metastasis from esophageal carcinoma is uncommon. The aims of this study were to assess the frequency of brain metastasis from esophageal carcinoma, describe treatment modalities and their outcomes, and determine predictors of survival. Methods: Between 2004 and 2012, 680 patients with esophageal carcinoma were registered at Keio University Hospital, Tokyo, Japan. Of these patients, 16 (2.3 %) were diagnosed with brain metastasis. We reviewed their medical records and performed statistical analyses. Results: The median survival after diagnosis of brain metastasis was 5.0 months (95 % CI 1.2-8.7 months). The only statistically significant baseline characteristic that predicted worse survival from brain metastasis was the onset form of brain metastasis (p = 0.01). At the onset of brain metastasis, the median survival from brain metastasis was 13.0 months (95 % CI 0.0-31.0 months) in patients without extracranial metastasis and 2.0 months (95 % CI 0.0-4.3 months) in patients with extracranial metastasis (p = 0.01). Conclusions: Approximately 2 % patients with esophageal carcinoma were diagnosed with brain metastasis. The prognosis of brain metastasis is extremely poor, but long-term survival may be expected with intensive treatment for brain metastasis when the first metastatic site is the brain.

KW - Brain metastasis

KW - Esophageal carcinoma

UR - http://www.scopus.com/inward/record.url?scp=84906944543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906944543&partnerID=8YFLogxK

U2 - 10.1007/s10388-014-0434-8

DO - 10.1007/s10388-014-0434-8

M3 - Article

AN - SCOPUS:84906944543

VL - 11

SP - 217

EP - 222

JO - Esophagus

JF - Esophagus

SN - 1612-9059

IS - 4

ER -