Clinical Features of Ground Glass Opacity–Dominant Lung Cancer Exceeding 3.0 cm in the Whole Tumor Size

Shigeki Suzuki, Hiroyuki Sakurai, Masaya Yotsukura, Kyohei Masai, Keisuke Asakura, Kazuo Nakagawa, Noriko Motoi, Shun ichi Watanabe

研究成果: Article

3 引用 (Scopus)

抄録

Background: Ground glass opacity (GGO)–dominant lung adenocarcinoma sized 3.0 cm or less in the whole tumor size is widely known to have an excellent prognosis and is regarded as early lung cancer. However, the characteristics and prognosis of lung cancer showing GGO exceeding 3.0 cm remains unclear. Methods: From 2002 through 2012, we reviewed 3,735 lung cancers that underwent complete resection at our institution. We identified 160 lung cancers (4.3%) showing GGO exceeding 3.0 cm on thin-section computed tomography and divided them into three types by the consolidation/tumor ratio (CTR) using cutoff values of 0.25 and 0.5. We compared the characteristics and prognosis among these types. Results: Type A (CTR, 0 to ≤0.25), type B (CTR, >0.25 to ≤0.5), and type C (CTR, >0.5 to <1.0) were found in 16 (10%), 37 (23%), and 107 lesions (67%), respectively. No lymph node metastasis was found in types A and B. Recurrence was not observed in types A and B. The 5-year overall survival and disease-free survival rates were both 100% in type A, both 97.2% in type B, and 88.4% and 66.7% in type C, respectively. Patients with type C had a significantly worse prognosis than those with the other types with respect to overall survival and disease-free survival. Conclusions: A patient with GGO-dominant lung cancer exceeding 3.0 cm can be considered to be in a group of patients with nodal-negative disease and an excellent prognosis.

元の言語English
ページ(範囲)1499-1506
ページ数8
ジャーナルAnnals of Thoracic Surgery
105
発行部数5
DOI
出版物ステータスPublished - 2018 5 1
外部発表Yes

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Glass
Lung Neoplasms
Neoplasms
Disease-Free Survival
Survival
Survival Rate
Lymph Nodes
Tomography
Neoplasm Metastasis
Recurrence

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

これを引用

Clinical Features of Ground Glass Opacity–Dominant Lung Cancer Exceeding 3.0 cm in the Whole Tumor Size. / Suzuki, Shigeki; Sakurai, Hiroyuki; Yotsukura, Masaya; Masai, Kyohei; Asakura, Keisuke; Nakagawa, Kazuo; Motoi, Noriko; Watanabe, Shun ichi.

:: Annals of Thoracic Surgery, 巻 105, 番号 5, 01.05.2018, p. 1499-1506.

研究成果: Article

Suzuki, S, Sakurai, H, Yotsukura, M, Masai, K, Asakura, K, Nakagawa, K, Motoi, N & Watanabe, SI 2018, 'Clinical Features of Ground Glass Opacity–Dominant Lung Cancer Exceeding 3.0 cm in the Whole Tumor Size', Annals of Thoracic Surgery, 巻. 105, 番号 5, pp. 1499-1506. https://doi.org/10.1016/j.athoracsur.2018.01.019
Suzuki, Shigeki ; Sakurai, Hiroyuki ; Yotsukura, Masaya ; Masai, Kyohei ; Asakura, Keisuke ; Nakagawa, Kazuo ; Motoi, Noriko ; Watanabe, Shun ichi. / Clinical Features of Ground Glass Opacity–Dominant Lung Cancer Exceeding 3.0 cm in the Whole Tumor Size. :: Annals of Thoracic Surgery. 2018 ; 巻 105, 番号 5. pp. 1499-1506.
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abstract = "Background: Ground glass opacity (GGO)–dominant lung adenocarcinoma sized 3.0 cm or less in the whole tumor size is widely known to have an excellent prognosis and is regarded as early lung cancer. However, the characteristics and prognosis of lung cancer showing GGO exceeding 3.0 cm remains unclear. Methods: From 2002 through 2012, we reviewed 3,735 lung cancers that underwent complete resection at our institution. We identified 160 lung cancers (4.3{\%}) showing GGO exceeding 3.0 cm on thin-section computed tomography and divided them into three types by the consolidation/tumor ratio (CTR) using cutoff values of 0.25 and 0.5. We compared the characteristics and prognosis among these types. Results: Type A (CTR, 0 to ≤0.25), type B (CTR, >0.25 to ≤0.5), and type C (CTR, >0.5 to <1.0) were found in 16 (10{\%}), 37 (23{\%}), and 107 lesions (67{\%}), respectively. No lymph node metastasis was found in types A and B. Recurrence was not observed in types A and B. The 5-year overall survival and disease-free survival rates were both 100{\%} in type A, both 97.2{\%} in type B, and 88.4{\%} and 66.7{\%} in type C, respectively. Patients with type C had a significantly worse prognosis than those with the other types with respect to overall survival and disease-free survival. Conclusions: A patient with GGO-dominant lung cancer exceeding 3.0 cm can be considered to be in a group of patients with nodal-negative disease and an excellent prognosis.",
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T1 - Clinical Features of Ground Glass Opacity–Dominant Lung Cancer Exceeding 3.0 cm in the Whole Tumor Size

AU - Suzuki, Shigeki

AU - Sakurai, Hiroyuki

AU - Yotsukura, Masaya

AU - Masai, Kyohei

AU - Asakura, Keisuke

AU - Nakagawa, Kazuo

AU - Motoi, Noriko

AU - Watanabe, Shun ichi

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Ground glass opacity (GGO)–dominant lung adenocarcinoma sized 3.0 cm or less in the whole tumor size is widely known to have an excellent prognosis and is regarded as early lung cancer. However, the characteristics and prognosis of lung cancer showing GGO exceeding 3.0 cm remains unclear. Methods: From 2002 through 2012, we reviewed 3,735 lung cancers that underwent complete resection at our institution. We identified 160 lung cancers (4.3%) showing GGO exceeding 3.0 cm on thin-section computed tomography and divided them into three types by the consolidation/tumor ratio (CTR) using cutoff values of 0.25 and 0.5. We compared the characteristics and prognosis among these types. Results: Type A (CTR, 0 to ≤0.25), type B (CTR, >0.25 to ≤0.5), and type C (CTR, >0.5 to <1.0) were found in 16 (10%), 37 (23%), and 107 lesions (67%), respectively. No lymph node metastasis was found in types A and B. Recurrence was not observed in types A and B. The 5-year overall survival and disease-free survival rates were both 100% in type A, both 97.2% in type B, and 88.4% and 66.7% in type C, respectively. Patients with type C had a significantly worse prognosis than those with the other types with respect to overall survival and disease-free survival. Conclusions: A patient with GGO-dominant lung cancer exceeding 3.0 cm can be considered to be in a group of patients with nodal-negative disease and an excellent prognosis.

AB - Background: Ground glass opacity (GGO)–dominant lung adenocarcinoma sized 3.0 cm or less in the whole tumor size is widely known to have an excellent prognosis and is regarded as early lung cancer. However, the characteristics and prognosis of lung cancer showing GGO exceeding 3.0 cm remains unclear. Methods: From 2002 through 2012, we reviewed 3,735 lung cancers that underwent complete resection at our institution. We identified 160 lung cancers (4.3%) showing GGO exceeding 3.0 cm on thin-section computed tomography and divided them into three types by the consolidation/tumor ratio (CTR) using cutoff values of 0.25 and 0.5. We compared the characteristics and prognosis among these types. Results: Type A (CTR, 0 to ≤0.25), type B (CTR, >0.25 to ≤0.5), and type C (CTR, >0.5 to <1.0) were found in 16 (10%), 37 (23%), and 107 lesions (67%), respectively. No lymph node metastasis was found in types A and B. Recurrence was not observed in types A and B. The 5-year overall survival and disease-free survival rates were both 100% in type A, both 97.2% in type B, and 88.4% and 66.7% in type C, respectively. Patients with type C had a significantly worse prognosis than those with the other types with respect to overall survival and disease-free survival. Conclusions: A patient with GGO-dominant lung cancer exceeding 3.0 cm can be considered to be in a group of patients with nodal-negative disease and an excellent prognosis.

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