Clinical, radiographic and functional effectiveness of tocilizumab for rheumatoid arthritis patients-REACTION 52-week study

Tsutomu Takeuchi, Yoshiya Tanaka, Koichi Amano, Daisuke Hoshi, Masao Nawata, Hayato Nagasawa, Eri Sato, Kazuyoshi Saito, Yuko Kaneko, Shunsuke Fukuyo, Takahiko Kurasawa, Kentaro Hanami, Hideto Kameda, Hisashi Yamanaka

研究成果: Article査読

66 被引用数 (Scopus)

抄録

Objectives: To evaluate the effectiveness and safety of tocilizumab in RA patients in clinical practice. Methods: We observed 232 consecutive RA patients who began tocilizumab in three rheumatology centres in Japan for 52 weeks. Clinical, radiographic and functional status and safety were evaluated. Results: Mean age of the 232 patients was 59.1 years, mean duration of disease was 12.4 years and average DAS using the 28-joint count (DAS-28) was 5.6. Although 62.8% of the patients had been treated previously with anti-TNF biologics, clinical remission at Week 52 was achieved in 43.7%, radiographic non-progression in 62.8% and functional remission in 26.4%. Retention rate at Week 52 was 71.1%, and the same for those with or without previous anti-TNF treatment. Adverse drug reactions leading to tocilizumab discontinuation were observed in 15.5% of patients, the most frequent adverse drug reaction being pneumonia in eight cases. On multivariate logistic regression analysis, DAS-28, HAQ-disability index (HAQ-DI), concomitant MTX and concomitant glucocorticoids (GCs) were predictive variables for clinical remission at Week 52 of tocilizumab treatment. In particular, HAQ-DI was found to be a predictive variable for remission of all three types-clinical, radiographic and functional-at Week 52 of tocilizumab treatment. Conclusions: In daily clinical practice, tocilizumab exhibited excellent effectiveness in established RA patients, some of whom had failed to respond to previous anti-TNF treatment. Although further detailed safety findings are required, this study provides valuable real-world findings on the management of RA with tocilizumab.

本文言語English
論文番号ker221
ページ(範囲)1908-1915
ページ数8
ジャーナルRheumatology
50
10
DOI
出版ステータスPublished - 2011 10

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

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