Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE)

K. Aoki, T. Takeuchi, I. Itoh, Y. Takano, T. Itoh, O. Hosono, J. Koide, T. Abe

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Anti-cardiolipin antibody (aCL) in SLE patients reacts with cardiolipin/beta 2-GP1 complex. In order to disclose clinical significance of aCL in patients with SLE, aCL was determined by newly-developed anti-CL.beta 2-GP1 kit [Yamasa] EIA in 58 patients with SLE and the relationship between clinical manifestation of SLE and the presence of aCL was examined. Anti-cardiolipin antibody was positive in 20 patients (34.5%). In 20 SLE patients with positive aCL, livedo reticularis in 7, retinal vein thrombosis in 3, thrombophlebitis in 3 and other vasculo-occlusive episodes were observed as a characteristic clinical features of positive aCL. In contrast, a SLE patient complicated by ileal perforation due to necrotizing angiitis had negative aCL. Other clinical and laboratory features associated with aCL include recurrent fetal loss and thrombocytopenia.

本文言語English
ページ(範囲)961-966
ページ数6
ジャーナルRyūmachi. [Rheumatism]
34
6
出版ステータスPublished - 1994 12
外部発表はい

ASJC Scopus subject areas

  • リウマチ学

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