Clinical significance of sentinel node navigation surgery in the treatment of early gastric cancer

Yuukou Kitagawa, T. Kubota, Y. Otani, Toshiharu Furukawa, M. Yoshida, H. Fujii, A. Kubo, M. Mukai, K. Kumai, M. Kitajima

研究成果: Article

13 引用 (Scopus)

抄録

Radical lymphadenectomy is the standard surgical approach even for early-stage gastric cancer with a relatively low incidence of lymph node metastasis because of the limited sensitivity of diagnostic imaging to detect micrometastasis in regional lymph nodes. The sentinel node (SN) concept is one topic among novel diagnostic procedures for micrometastasis. The SN is defined as the first draining node from the primary lesion and it would be the first site of micrometastasis. SN biopsy has been clinically validated and applied for the surgical treatment of malignant melanoma and breast cancer. Although the feasibility of this technique in other solid tumors including gastric cancer is still controversial, there are several reports demonstrating the diagnostic significance of SN mapping in early gastric cancer. We have established radio-guided SN mapping for early gastric cancer, and the diagnostic accuracy using this procedure in cT1N0 cases reached 98%. The radio-guided method allows us to detect the SN in endoscopic surgery quantitatively and reproducibly. Validation of the SN concept in gastric cancer in a multi-centric clinical trial is essential for clinical application of this procedure, including the establishment of a novel, minimally invasive approach for early-stage gastric cancer.

元の言語English
ページ(範囲)753-757
ページ数5
ジャーナルNippon Geka Gakkai zasshi
102
発行部数10
出版物ステータスPublished - 2001

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Stomach Neoplasms
Neoplasm Micrometastasis
Radio
Lymph Nodes
Diagnostic Imaging
cyhalothrin
Lymph Node Excision
Melanoma
Clinical Trials
Breast Neoplasms
Neoplasm Metastasis
Biopsy
Incidence
Neoplasms

これを引用

Clinical significance of sentinel node navigation surgery in the treatment of early gastric cancer. / Kitagawa, Yuukou; Kubota, T.; Otani, Y.; Furukawa, Toshiharu; Yoshida, M.; Fujii, H.; Kubo, A.; Mukai, M.; Kumai, K.; Kitajima, M.

:: Nippon Geka Gakkai zasshi, 巻 102, 番号 10, 2001, p. 753-757.

研究成果: Article

Kitagawa, Y, Kubota, T, Otani, Y, Furukawa, T, Yoshida, M, Fujii, H, Kubo, A, Mukai, M, Kumai, K & Kitajima, M 2001, 'Clinical significance of sentinel node navigation surgery in the treatment of early gastric cancer', Nippon Geka Gakkai zasshi, 巻. 102, 番号 10, pp. 753-757.
Kitagawa, Yuukou ; Kubota, T. ; Otani, Y. ; Furukawa, Toshiharu ; Yoshida, M. ; Fujii, H. ; Kubo, A. ; Mukai, M. ; Kumai, K. ; Kitajima, M. / Clinical significance of sentinel node navigation surgery in the treatment of early gastric cancer. :: Nippon Geka Gakkai zasshi. 2001 ; 巻 102, 番号 10. pp. 753-757.
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abstract = "Radical lymphadenectomy is the standard surgical approach even for early-stage gastric cancer with a relatively low incidence of lymph node metastasis because of the limited sensitivity of diagnostic imaging to detect micrometastasis in regional lymph nodes. The sentinel node (SN) concept is one topic among novel diagnostic procedures for micrometastasis. The SN is defined as the first draining node from the primary lesion and it would be the first site of micrometastasis. SN biopsy has been clinically validated and applied for the surgical treatment of malignant melanoma and breast cancer. Although the feasibility of this technique in other solid tumors including gastric cancer is still controversial, there are several reports demonstrating the diagnostic significance of SN mapping in early gastric cancer. We have established radio-guided SN mapping for early gastric cancer, and the diagnostic accuracy using this procedure in cT1N0 cases reached 98{\%}. The radio-guided method allows us to detect the SN in endoscopic surgery quantitatively and reproducibly. Validation of the SN concept in gastric cancer in a multi-centric clinical trial is essential for clinical application of this procedure, including the establishment of a novel, minimally invasive approach for early-stage gastric cancer.",
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AU - Kubota, T.

AU - Otani, Y.

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AU - Yoshida, M.

AU - Fujii, H.

AU - Kubo, A.

AU - Mukai, M.

AU - Kumai, K.

AU - Kitajima, M.

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N2 - Radical lymphadenectomy is the standard surgical approach even for early-stage gastric cancer with a relatively low incidence of lymph node metastasis because of the limited sensitivity of diagnostic imaging to detect micrometastasis in regional lymph nodes. The sentinel node (SN) concept is one topic among novel diagnostic procedures for micrometastasis. The SN is defined as the first draining node from the primary lesion and it would be the first site of micrometastasis. SN biopsy has been clinically validated and applied for the surgical treatment of malignant melanoma and breast cancer. Although the feasibility of this technique in other solid tumors including gastric cancer is still controversial, there are several reports demonstrating the diagnostic significance of SN mapping in early gastric cancer. We have established radio-guided SN mapping for early gastric cancer, and the diagnostic accuracy using this procedure in cT1N0 cases reached 98%. The radio-guided method allows us to detect the SN in endoscopic surgery quantitatively and reproducibly. Validation of the SN concept in gastric cancer in a multi-centric clinical trial is essential for clinical application of this procedure, including the establishment of a novel, minimally invasive approach for early-stage gastric cancer.

AB - Radical lymphadenectomy is the standard surgical approach even for early-stage gastric cancer with a relatively low incidence of lymph node metastasis because of the limited sensitivity of diagnostic imaging to detect micrometastasis in regional lymph nodes. The sentinel node (SN) concept is one topic among novel diagnostic procedures for micrometastasis. The SN is defined as the first draining node from the primary lesion and it would be the first site of micrometastasis. SN biopsy has been clinically validated and applied for the surgical treatment of malignant melanoma and breast cancer. Although the feasibility of this technique in other solid tumors including gastric cancer is still controversial, there are several reports demonstrating the diagnostic significance of SN mapping in early gastric cancer. We have established radio-guided SN mapping for early gastric cancer, and the diagnostic accuracy using this procedure in cT1N0 cases reached 98%. The radio-guided method allows us to detect the SN in endoscopic surgery quantitatively and reproducibly. Validation of the SN concept in gastric cancer in a multi-centric clinical trial is essential for clinical application of this procedure, including the establishment of a novel, minimally invasive approach for early-stage gastric cancer.

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