Clinical utility of insulin-like growth factor binding protein-3 in the evaluation and treatment of short children with suspected growth hormone deficiency

Y. Hasegawa, T. Hasegawa, T. Aso, S. Kotoh, O. Nose, Y. Ohyama, K. Araki, T. Tanaka, S. Saisyo, S. Yokoya, Y. Nishi, S. Miyamoto, N. Sasaki, F. Kurimoto, M. Stene, Y. Tsuchiya

研究成果: Article査読

57 被引用数 (Scopus)

抄録

We have shown previously that serum insulin-like growth factor binding protein-3 (IGPBP-3) levels have good predictive value for complete, but not partial, growth hormone deficiency (GHD). In this study, we compare TGFBP-3 levels in short children previously divided into groups on the basis of their post-stimulation GH levels. Complete GHD (N = 59) included those children with peak post-stimulation GH < 5 μg/l. The partial GHD group (N = 49) had post-stimulation GH peaks of > 5 μg/l but < 10 μg/l. The normal children with short stature (N = 103) had post-stimulation GH peaks > 10 μg/l. Partial GHD and normal children with short stature also were divided into either low IGF-I or normal IGF-I subgroups. The clinical sensitivity of IGFBP-3 for complete GHD was 92%, whereas its sensitivity for partial GHD was 39%. For partial GHD, among those with low IGF-I (N = 19) 68% were also low for IGFBP-3, while 80% of those with normal IGF-I (N = 30) were also normal for IGFBP-3, The clinical specificity of IGFBP-3 for normal children with short stature was 69%. For these groups, among those with low TGF-I (N = 22) 73% also were low for IGFBP-3, while 80% of those with normal IGF-I (N = 81) also were normal for IGFBP-3. In addition, we tested whether IGFBP-3 can predict the response to GH treatment in prepubertal children by comparing pretreatment IGFBP-3 with the height gain achieved by 1 year of GH treatment. The incremental growth velocity during treatment correlated significantly with the pretreatment IGFBP-3 SD score (N = 46 r = -0.80, p < 0.005). The baseline IGFBP-3 so score for all subjects correlated (N = 171, r = 0.51 p < 0.0001) with height. These data suggest that IGFBP-3 may reflect GH secretion status in most children being evaluated for GHD and that a low pretreatment IGFBP-3 so score predicts improved growth during the first year of GH treatment.

本文言語English
ページ(範囲)27-32
ページ数6
ジャーナルEuropean journal of endocrinology
131
1
DOI
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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