Clinicopathological analyses in patients with other iatrogenic immunodeficiency-associated lymphoproliferative diseases and rheumatoid arthritis

Michihide Tokuhira, Reiko Watanabe, Tomoe Nemoto, Morihiko Sagawa, Tatsuki Tomikawa, Jun Ichi Tamaru, Shinji Itoyama, Hayato Nagasawa, Koichi Amano, Hideto Kameda, Tsutomu Takeuchi, Shigehisa Mori, Masahiro Kizaki

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Despite numerous attempts to uncover the mechanism of other iatrogenic immunodeficiency-associated lymphoproliferative diseases (OIIA-LPDs), this mechanism remains poorly understood, especially in rheumatoid arthritis (RA) patients. We analyzed the data on 23 patients with LPDs and RA. Patients were categorized into three groups according to whether they had methotrexate (MTX); MTX-regressive LPDs, MTX-persistent LPDs or other drugs-mediated LPDs. The LPDs seen in OIIA-LPDs-RA might have a unique behavior to think about several rare phenotypes. The overall survival of all patients was 74% at 5 years, and those of the three groups were 100%, 64% and 60%, respectively. Among the 6 patients who died, 4 had LPDs that were detected late, and thus adequate treatment was not given. In addition, several patients with diffuse large B cell lymphoma with a complex karyotype achieved complete remission (CR). Only one among the 17 patients who achieved CR relapsed. OIIA-LPDs-RA appeared to have a better prognosis than other more common types of lymphomas. Regarding RA treatment, various anti-RA drugs were given to the patients after developing LPDs, including MTX, but no recurrent patients were documented.

本文言語English
ページ(範囲)616-623
ページ数8
ジャーナルLeukemia and Lymphoma
53
4
DOI
出版ステータスPublished - 2012 4

ASJC Scopus subject areas

  • 血液学
  • 腫瘍学
  • 癌研究

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