Clinicopathological study on para-aortic lymph node metastasis without pelvic lymph node metastasis in endometrial cancer

Shoko Tomisato, Wataru Yamagami, Nobuyuki Susumu, Michiko Kuwahata, Aya Takigawa, Hiroyuki Nomura, Fumio Kataoka, Akira Hirasawa, Kouji Banno, Daisuke Aoki

研究成果: Article

7 引用 (Scopus)

抄録

Aim One of the important risk factors for recurrence of endometrial cancer is lymph node metastasis. The regional lymph nodes are pelvic lymph nodes (PLN) and para-aortic lymph nodes (PAN). PAN metastasis was often detected in the cases with PLN metastasis. However, PAN metastasis not associated with PLN metastasis was identified in a few cases. We focused on nine cases with PAN metastasis and without PLN metastasis. Material and Methods The subjects of this study were 260 cases that were diagnosed with endometrial cancer. The initial treatments were surgery, including pelvic and para-aortic lymphadenectomy. Nine of these cases had PAN metastasis but did not have PLN metastasis. We retrospectively analyzed the clinicopathological factors and prognosis in cases with PLN-PAN+ cases. Results A total of 91 (35%) cases were identified as positive for either PLN or PAN. PAN metastases were detected in 62.6% of the cases that had some regional lymph node metastases and 3.5% of all cases were PLN- and PAN+. In all PLN-PAN+ cases, PAN swelling was not detected by preoperative chest-abdominal computed tomography scan. There were no clear trends among risk factors of regional lymph node metastasis. The 5-year progression-free survival was 87.1% for PLN-PAN- cases, 67.5% for PLN+PAN- cases, 44.4% for PLN-PAN+ cases, and 33.2% for PLN+PAN+ cases. Conclusion During diagnosis and treatment for endometrial cancer, PLN-PAN+ cases should also be considered because the prognosis in PLN-PAN+ cases tended to be lower than that in PLN-PAN- cases and PLN+PAN- cases.

元の言語English
ページ(範囲)1733-1739
ページ数7
ジャーナルJournal of Obstetrics and Gynaecology Research
40
発行部数6
DOI
出版物ステータスPublished - 2014

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Endometrial Neoplasms
Lymph Nodes
Neoplasm Metastasis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Medicine(all)

これを引用

Clinicopathological study on para-aortic lymph node metastasis without pelvic lymph node metastasis in endometrial cancer. / Tomisato, Shoko; Yamagami, Wataru; Susumu, Nobuyuki; Kuwahata, Michiko; Takigawa, Aya; Nomura, Hiroyuki; Kataoka, Fumio; Hirasawa, Akira; Banno, Kouji; Aoki, Daisuke.

:: Journal of Obstetrics and Gynaecology Research, 巻 40, 番号 6, 2014, p. 1733-1739.

研究成果: Article

Tomisato, Shoko ; Yamagami, Wataru ; Susumu, Nobuyuki ; Kuwahata, Michiko ; Takigawa, Aya ; Nomura, Hiroyuki ; Kataoka, Fumio ; Hirasawa, Akira ; Banno, Kouji ; Aoki, Daisuke. / Clinicopathological study on para-aortic lymph node metastasis without pelvic lymph node metastasis in endometrial cancer. :: Journal of Obstetrics and Gynaecology Research. 2014 ; 巻 40, 番号 6. pp. 1733-1739.
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title = "Clinicopathological study on para-aortic lymph node metastasis without pelvic lymph node metastasis in endometrial cancer",
abstract = "Aim One of the important risk factors for recurrence of endometrial cancer is lymph node metastasis. The regional lymph nodes are pelvic lymph nodes (PLN) and para-aortic lymph nodes (PAN). PAN metastasis was often detected in the cases with PLN metastasis. However, PAN metastasis not associated with PLN metastasis was identified in a few cases. We focused on nine cases with PAN metastasis and without PLN metastasis. Material and Methods The subjects of this study were 260 cases that were diagnosed with endometrial cancer. The initial treatments were surgery, including pelvic and para-aortic lymphadenectomy. Nine of these cases had PAN metastasis but did not have PLN metastasis. We retrospectively analyzed the clinicopathological factors and prognosis in cases with PLN-PAN+ cases. Results A total of 91 (35{\%}) cases were identified as positive for either PLN or PAN. PAN metastases were detected in 62.6{\%} of the cases that had some regional lymph node metastases and 3.5{\%} of all cases were PLN- and PAN+. In all PLN-PAN+ cases, PAN swelling was not detected by preoperative chest-abdominal computed tomography scan. There were no clear trends among risk factors of regional lymph node metastasis. The 5-year progression-free survival was 87.1{\%} for PLN-PAN- cases, 67.5{\%} for PLN+PAN- cases, 44.4{\%} for PLN-PAN+ cases, and 33.2{\%} for PLN+PAN+ cases. Conclusion During diagnosis and treatment for endometrial cancer, PLN-PAN+ cases should also be considered because the prognosis in PLN-PAN+ cases tended to be lower than that in PLN-PAN- cases and PLN+PAN- cases.",
keywords = "endometrial cancer, para-aortic lymph node metastasis, pelvic lymph node metastasis",
author = "Shoko Tomisato and Wataru Yamagami and Nobuyuki Susumu and Michiko Kuwahata and Aya Takigawa and Hiroyuki Nomura and Fumio Kataoka and Akira Hirasawa and Kouji Banno and Daisuke Aoki",
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TY - JOUR

T1 - Clinicopathological study on para-aortic lymph node metastasis without pelvic lymph node metastasis in endometrial cancer

AU - Tomisato, Shoko

AU - Yamagami, Wataru

AU - Susumu, Nobuyuki

AU - Kuwahata, Michiko

AU - Takigawa, Aya

AU - Nomura, Hiroyuki

AU - Kataoka, Fumio

AU - Hirasawa, Akira

AU - Banno, Kouji

AU - Aoki, Daisuke

PY - 2014

Y1 - 2014

N2 - Aim One of the important risk factors for recurrence of endometrial cancer is lymph node metastasis. The regional lymph nodes are pelvic lymph nodes (PLN) and para-aortic lymph nodes (PAN). PAN metastasis was often detected in the cases with PLN metastasis. However, PAN metastasis not associated with PLN metastasis was identified in a few cases. We focused on nine cases with PAN metastasis and without PLN metastasis. Material and Methods The subjects of this study were 260 cases that were diagnosed with endometrial cancer. The initial treatments were surgery, including pelvic and para-aortic lymphadenectomy. Nine of these cases had PAN metastasis but did not have PLN metastasis. We retrospectively analyzed the clinicopathological factors and prognosis in cases with PLN-PAN+ cases. Results A total of 91 (35%) cases were identified as positive for either PLN or PAN. PAN metastases were detected in 62.6% of the cases that had some regional lymph node metastases and 3.5% of all cases were PLN- and PAN+. In all PLN-PAN+ cases, PAN swelling was not detected by preoperative chest-abdominal computed tomography scan. There were no clear trends among risk factors of regional lymph node metastasis. The 5-year progression-free survival was 87.1% for PLN-PAN- cases, 67.5% for PLN+PAN- cases, 44.4% for PLN-PAN+ cases, and 33.2% for PLN+PAN+ cases. Conclusion During diagnosis and treatment for endometrial cancer, PLN-PAN+ cases should also be considered because the prognosis in PLN-PAN+ cases tended to be lower than that in PLN-PAN- cases and PLN+PAN- cases.

AB - Aim One of the important risk factors for recurrence of endometrial cancer is lymph node metastasis. The regional lymph nodes are pelvic lymph nodes (PLN) and para-aortic lymph nodes (PAN). PAN metastasis was often detected in the cases with PLN metastasis. However, PAN metastasis not associated with PLN metastasis was identified in a few cases. We focused on nine cases with PAN metastasis and without PLN metastasis. Material and Methods The subjects of this study were 260 cases that were diagnosed with endometrial cancer. The initial treatments were surgery, including pelvic and para-aortic lymphadenectomy. Nine of these cases had PAN metastasis but did not have PLN metastasis. We retrospectively analyzed the clinicopathological factors and prognosis in cases with PLN-PAN+ cases. Results A total of 91 (35%) cases were identified as positive for either PLN or PAN. PAN metastases were detected in 62.6% of the cases that had some regional lymph node metastases and 3.5% of all cases were PLN- and PAN+. In all PLN-PAN+ cases, PAN swelling was not detected by preoperative chest-abdominal computed tomography scan. There were no clear trends among risk factors of regional lymph node metastasis. The 5-year progression-free survival was 87.1% for PLN-PAN- cases, 67.5% for PLN+PAN- cases, 44.4% for PLN-PAN+ cases, and 33.2% for PLN+PAN+ cases. Conclusion During diagnosis and treatment for endometrial cancer, PLN-PAN+ cases should also be considered because the prognosis in PLN-PAN+ cases tended to be lower than that in PLN-PAN- cases and PLN+PAN- cases.

KW - endometrial cancer

KW - para-aortic lymph node metastasis

KW - pelvic lymph node metastasis

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U2 - 10.1111/jog.12399

DO - 10.1111/jog.12399

M3 - Article

C2 - 24888941

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VL - 40

SP - 1733

EP - 1739

JO - Asia-Oceania Journal of Obstetrics and Gynaecology

JF - Asia-Oceania Journal of Obstetrics and Gynaecology

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