Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor

Yutaka Kawakami, Siona Eliyahu, Cynthia H. Delgado, Paul F. Robbins, Licia Rivoltini, Suzanne L. Topalian, Toru Miki, Steven A. Rosenberg

研究成果: Article査読

1020 被引用数 (Scopus)

抄録

By cDNA expression cloning we have isolated a gene encoding a shared human melanoma antigen recognized by HLA-A2 restricted autologous and allogeneic tumor-infiltrating lymphocytes (TILs) from patients with metastatic melanoma. By using both transient and stable expression systems, transfection of this gene into non-antigen-expressing HLA-A2+ cell lines resulted in recognition by the antigen-specific TILs. The sequence of this cDNA revealed a previously undescribed putative transmembrane protein whose expression was restricted to melanoma and melanocyte cell lines and human retina but no other fresh or cultured normal tissues tested or other tumor histologies. Thus, we have identified a gene encoding a melanocyte lineage-specific protein (MART-1; melanoma antigen recognized by T cells 1) that is a widely shared melanoma antigen recognized by the T lymphocytes of patients with established malignancy. Identification of this gene opens possibilities for the development of immunotherapies for patients with melanoma.

本文言語English
ページ(範囲)3515-3519
ページ数5
ジャーナルProceedings of the National Academy of Sciences of the United States of America
91
9
DOI
出版ステータスPublished - 1994 4月 26

ASJC Scopus subject areas

  • 一般

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