CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis

Hiroaki Obata, Bobby Yanagawa, Koichi Tanaka, Shunsuke Ohnishi, Masaharu Kataoka, Yoshinori Miyahara, Hatsue Ishibashi-Ueda, Makoto Kodama, Yoshifusa Aizawa, Kenji Kangawa, Noritoshi Nagaya

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Myocarditis is an acute inflammatory disease of the myocardium for which there is currently no specific therapy. We investigated the therapeutic potential of C-type natriuretic peptide (CNP) in acute experimental autoimmune myocarditis. One week after injection of porcine myosin into male Lewis rats, CNP (0.05 μg/kg/min) was continuously administered for 2 weeks. CNP infusion significantly increased maximum dP/dt, decreased left ventricular end-diastolic pressure, and improved fractional shortening compared with vehicle administration. In vehicle-treated hearts, severe necrosis and marked infiltration of CD68-positive inflammatory cells were observed. Myocardial and serum levels of monocyte chemoattractant protein-1 were elevated in myocarditis. However, these changes were attenuated by CNP infusion. In addition, treatment with CNP significantly increased myocardial capillary density. Guanylyl cyclase-B, a receptor for CNP, was expressed in myocarditic heart, and cyclic guanosine monophosphate was elevated by CNP infusion. In conclusion, CNP infusion attenuated cardiac function in acute myocarditis through anti-inflammatory and angiogenic effects.

本文言語English
ページ(範囲)60-66
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
356
1
DOI
出版ステータスPublished - 2007 4 27
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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