Cohort studies of effects of long-term toluene diisocyanate (TDI) exposure on pulmonary function

K. Omae

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

Toluene diisocyanates (C6H3CH3 (NCO)2, TDIs) are synthetic low molecular-weight organic chemicals with two highly reactive isocyanate groups (-NCO). Exposure to TDI can cause irritation of the eyes, nose, and upper and lower respiratory tract, asthma-like responses, sensitive pneumonitis, and obstructive pulmonary function loss. In this paper, the exposure-effect relationships between long-term TDI exposure and its effect on pulmonary function are summarized by evaluating the results of cohort studies, including 2 cohort studies conducted by the author's research team, which were specially devoted to the exposure-effect relationships and were published at the end of 1992. By assessing the exposure-effect relationships, the current occupational exposure limit of TDI in Japan is discussed and a framework for the health checks on TDI-exposed workers is proposed.

本文言語English
ページ(範囲)1017-1026
ページ数10
ジャーナルJapanese Journal of Hygiene
48
6
DOI
出版ステータスPublished - 1993

ASJC Scopus subject areas

  • 医学(全般)

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