Collagen immobilized PVA hydrogel-hydroxyapatite composites prepared by kneading methods as a material for peripheral cuff of artificial cornea

Hisatoshi Kobayashi, Masabumi Kato, Tetsushi Taguchi, Toshiyuki Ikoma, Hideyuki Miyashita, Shigeto Shimmura, Kazuo Tsubota, Junzo Tanaka

研究成果: Article

61 引用 (Scopus)

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In order to achieve the firm fixation of the artificial cornea to host tissues, composites of collagen-immobilized poly(vinyl alcohol) hydrogel with hydroxyapatite were synthesized by a hydroxyapatite particles kneading method. The preparation method, characterization, and the results of corneal cell adhesion and proliferation on the composite material were studied. PVA-COL-HAp composites were successfully synthesized. A micro-porous structure of the PVA-COL-HAp could be introduced by hydrochloric acid treatment and the porosity could be controlled by the pH of the hydrochloric acid solution, the treatment time, and the crystallinity of the HAp particles, Chick embryonic keratocyto-like cells were well attached and proliferated on the PVA-COL-HAp composites. This material showed potential for keratoprosthesis application. Further study such as a long-term animal study is now required.

元の言語English
ページ(範囲)729-735
ページ数7
ジャーナルMaterials Science and Engineering C
24
発行部数6-8 SPEC. ISS.
DOI
出版物ステータスPublished - 2004 12 1
外部発表Yes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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