Collagen-silicone hybrid microtube device for 3D-layered tissue culture with perfusion

H. Tajima, Hiroaki Onoe

研究成果: Conference contribution

1 引用 (Scopus)

抜粋

We present a perfusable collagen-silicone hybrid microtube device for three-dimensional (3D) tissue culture mimicking microenvironment in vivo. Our device is composed of a collagen hydrogel microtube that are directly connected to two silicone tubes. In the collagen microtube, multiple types of cells can be cultured in 3D extracellular matrix (ECM) microenvironment with perfusion. The connected silicone tubes enable us to connect an external pump system easily. We confirmed that cells can be cultured in our device and perfusion assay can be performed by testing the alignment of actin filaments in endothelial cells by fluid shear stress. Our collagen tube device could be a simple but easy-to-use in vitro perfusable 3D tissue models for drug testing and regenerative medicine.

元の言語English
ホスト出版物のタイトル20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
出版者Chemical and Biological Microsystems Society
ページ419-420
ページ数2
ISBN(電子版)9780979806490
出版物ステータスPublished - 2016
イベント20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
継続期間: 2016 10 92016 10 13

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Ireland
Dublin
期間16/10/916/10/13

    フィンガープリント

ASJC Scopus subject areas

  • Control and Systems Engineering

これを引用

Tajima, H., & Onoe, H. (2016). Collagen-silicone hybrid microtube device for 3D-layered tissue culture with perfusion. : 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 419-420). Chemical and Biological Microsystems Society.