Collagenase inhibitors from Viola yedoensis

Naohiro Oshima, Yuji Narukawa, Tadahiro Takeda, Fumiyuki Kiuchi

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Fractionation of acetone and methanol extracts of Viola yedoensis, under the guidance of inhibition against Clostridium histolyticum collagenase (ChC), resulted in the isolation of esculetin (1) (IC50 12 μM) and scopoletin (2) (IC50 1.8 μM) as the active constituents, together with trans-p-coumaric acid (3), cis-p-coumaric acid (4), 3-O-β-d-glucosyl- 7-O-α-L-rhamnosylkaempferol (5), rutin (6), isovitexin (7), isoorientin (8), vicenin-2 (9), isoscoparin (10), vanillic acid (11) and adenosine (12). Modification of phenolic hydroxy groups of 1 showed that small O-alkyl groups largely increased the activity, whereas larger O-alkyl groups decreased the activity, and 6,7-dimethoxycoumarin (scoparone 13) potently inhibited ChC (IC50 24 nM).

本文言語English
ページ(範囲)240-245
ページ数6
ジャーナルJournal of Natural Medicines
67
1
DOI
出版ステータスPublished - 2013 1

ASJC Scopus subject areas

  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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