Collective Oscillation Period of Inter-Coupled Biological Negative Cyclic Feedback Oscillators

Yongqiang Wang, Yutaka Hori, Shinji Hara, Francis J. Doyle

研究成果: Article

5 引用 (Scopus)

抜粋

A number of biological rhythms originate from networks comprised of multiple cellular oscillators. But analytical results are still lacking on the collective oscillation period of inter-coupled gene regulatory oscillators, which, as has been reported, may be different from that of an autonomous oscillator. Based on cyclic feedback oscillators, we analyze the collective oscillation pattern of coupled cellular oscillators. First we give a condition under which the oscillator network exhibits oscillatory and synchronized behavior. Then we estimate the collective oscillation period based on a novel multivariable harmonic balance technique. Analytical results are derived in terms of biochemical parameters, thus giving insight into the basic mechanism of biological oscillation and providing guidance in synthetic biology design.

元の言語English
記事番号6862832
ページ(範囲)1392-1397
ページ数6
ジャーナルIEEE Transactions on Automatic Control
60
発行部数5
DOI
出版物ステータスPublished - 2015 5 1
外部発表Yes

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Computer Science Applications
  • Electrical and Electronic Engineering

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