Combination of quantitative changes in ionic components to enhance the contractile force during T-tubule development

Maiko Wakita, Hitomi I. Sano, Yasuhiro Naito, Masaru Tomita

研究成果: Conference contribution

抄録

During rodent ventricular cell development, the sarcoplasmic reticulum (SR) is scarce and poorly organized. A Ca2+ transient in embryonic ventricular cells depends mostly on Ca2+ influx through L-type Ca2+ channels. In rat ventricular cells, transverse tubules (t-tubules) begin to form postnatally. As such, Ca2+-induced Ca2+ release (CICR), in which ryanodine receptor channels on the SR are activated via Ca2+ influx through L-type Ca2+ channels on the t-tubules, is not established in embryonic ventricular cells. Here, we modeled developmental changes in Guinea pig ventricular cells and identified the factors that enhance contraction of the cells with an increase in CICR.

本文言語English
ホスト出版物のタイトルComputing in Cardiology Conference, CinC 2016
編集者Alan Murray
出版社IEEE Computer Society
ページ1093-1096
ページ数4
ISBN(電子版)9781509008964
DOI
出版ステータスPublished - 2016 3 1
イベント43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada
継続期間: 2016 9 112016 9 14

出版物シリーズ

名前Computing in Cardiology
43
ISSN(印刷版)2325-8861
ISSN(電子版)2325-887X

Other

Other43rd Computing in Cardiology Conference, CinC 2016
国/地域Canada
CityVancouver
Period16/9/1116/9/14

ASJC Scopus subject areas

  • コンピュータ サイエンス(全般)
  • 循環器および心血管医学

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