Combined analysis of polymorphisms in angiotensinogen and adducin genes and their effects on hypertension in a Japanese sample: The Shigaraki study

Shinji Tamaki, Yasuyuki Nakamura, Yasuharu Tabara, Tomonori Okamura, Yoshikuni Kita, Takashi Kodawaki, Yasuyuki Tsujita, Minoru Horie, Tetsuro Miki, Hirotsugu Ueshima

研究成果: Article

15 引用 (Scopus)

抄録

We examined the interactions between lifestyle and polymorphisms of salt-sensitive genes and their effects on hypertension in a general Japanese sample (The Shigaraki Study). The study group consisted of 2,902 subjects who underwent a medical examination in 1999 in Shigaraki, a suburban area in Shiga. Among 1,647 subjects not receiving antihypertensive medication, in a combined analysis of angiotensinogen (AGT) and adducin (ADD1) polymorphisms, double homozygosity of 235Trp or 460Trp was not found to be associated with hypertension. A multiple logistic regression analysis showed that age (odds ratio [OR]: 1.07, 95% confidence interval [95% CI]: 1.06-1.08), body mass index (BMI) (OR: 1.18, 95% CI: 1.13-1.23), alcohol consumption (OR: 1.39, 95% CI: 1.16-1.66), family history of hypertension (OR: 1.57, 95% CI: 1.18-2.07), and combined AGT M235T Thr/Thr and ADD1 Trp/Trp polymorphisms (OR: 1.37, 95% CI: 1.03-1.82) were associated with hypertension. However, there was no interaction between eating salty food and combined AGT and ADD1 polymorphisms. Furthermore, eating salty food was not associated with hypertension in a multivariate analysis. Therefore, a combination of the AGT and ADD1 polymorphisms appears to be associated with hypertension. However, a simple questionnaire regarding salt intake was not sufficient to confirm the relationship between salt intake and hypertension and/or salt-sensitive genes.

元の言語English
ページ(範囲)645-650
ページ数6
ジャーナルHypertension Research
28
発行部数8
DOI
出版物ステータスPublished - 2005 8
外部発表Yes

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Angiotensinogen
Hypertension
Odds Ratio
Confidence Intervals
Genes
Salts
Eating
Food
adducin
Alcohol Drinking
Antihypertensive Agents
Life Style
Body Mass Index
Multivariate Analysis
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Internal Medicine

これを引用

Combined analysis of polymorphisms in angiotensinogen and adducin genes and their effects on hypertension in a Japanese sample : The Shigaraki study. / Tamaki, Shinji; Nakamura, Yasuyuki; Tabara, Yasuharu; Okamura, Tomonori; Kita, Yoshikuni; Kodawaki, Takashi; Tsujita, Yasuyuki; Horie, Minoru; Miki, Tetsuro; Ueshima, Hirotsugu.

:: Hypertension Research, 巻 28, 番号 8, 08.2005, p. 645-650.

研究成果: Article

Tamaki, Shinji ; Nakamura, Yasuyuki ; Tabara, Yasuharu ; Okamura, Tomonori ; Kita, Yoshikuni ; Kodawaki, Takashi ; Tsujita, Yasuyuki ; Horie, Minoru ; Miki, Tetsuro ; Ueshima, Hirotsugu. / Combined analysis of polymorphisms in angiotensinogen and adducin genes and their effects on hypertension in a Japanese sample : The Shigaraki study. :: Hypertension Research. 2005 ; 巻 28, 番号 8. pp. 645-650.
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abstract = "We examined the interactions between lifestyle and polymorphisms of salt-sensitive genes and their effects on hypertension in a general Japanese sample (The Shigaraki Study). The study group consisted of 2,902 subjects who underwent a medical examination in 1999 in Shigaraki, a suburban area in Shiga. Among 1,647 subjects not receiving antihypertensive medication, in a combined analysis of angiotensinogen (AGT) and adducin (ADD1) polymorphisms, double homozygosity of 235Trp or 460Trp was not found to be associated with hypertension. A multiple logistic regression analysis showed that age (odds ratio [OR]: 1.07, 95{\%} confidence interval [95{\%} CI]: 1.06-1.08), body mass index (BMI) (OR: 1.18, 95{\%} CI: 1.13-1.23), alcohol consumption (OR: 1.39, 95{\%} CI: 1.16-1.66), family history of hypertension (OR: 1.57, 95{\%} CI: 1.18-2.07), and combined AGT M235T Thr/Thr and ADD1 Trp/Trp polymorphisms (OR: 1.37, 95{\%} CI: 1.03-1.82) were associated with hypertension. However, there was no interaction between eating salty food and combined AGT and ADD1 polymorphisms. Furthermore, eating salty food was not associated with hypertension in a multivariate analysis. Therefore, a combination of the AGT and ADD1 polymorphisms appears to be associated with hypertension. However, a simple questionnaire regarding salt intake was not sufficient to confirm the relationship between salt intake and hypertension and/or salt-sensitive genes.",
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AU - Tamaki, Shinji

AU - Nakamura, Yasuyuki

AU - Tabara, Yasuharu

AU - Okamura, Tomonori

AU - Kita, Yoshikuni

AU - Kodawaki, Takashi

AU - Tsujita, Yasuyuki

AU - Horie, Minoru

AU - Miki, Tetsuro

AU - Ueshima, Hirotsugu

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N2 - We examined the interactions between lifestyle and polymorphisms of salt-sensitive genes and their effects on hypertension in a general Japanese sample (The Shigaraki Study). The study group consisted of 2,902 subjects who underwent a medical examination in 1999 in Shigaraki, a suburban area in Shiga. Among 1,647 subjects not receiving antihypertensive medication, in a combined analysis of angiotensinogen (AGT) and adducin (ADD1) polymorphisms, double homozygosity of 235Trp or 460Trp was not found to be associated with hypertension. A multiple logistic regression analysis showed that age (odds ratio [OR]: 1.07, 95% confidence interval [95% CI]: 1.06-1.08), body mass index (BMI) (OR: 1.18, 95% CI: 1.13-1.23), alcohol consumption (OR: 1.39, 95% CI: 1.16-1.66), family history of hypertension (OR: 1.57, 95% CI: 1.18-2.07), and combined AGT M235T Thr/Thr and ADD1 Trp/Trp polymorphisms (OR: 1.37, 95% CI: 1.03-1.82) were associated with hypertension. However, there was no interaction between eating salty food and combined AGT and ADD1 polymorphisms. Furthermore, eating salty food was not associated with hypertension in a multivariate analysis. Therefore, a combination of the AGT and ADD1 polymorphisms appears to be associated with hypertension. However, a simple questionnaire regarding salt intake was not sufficient to confirm the relationship between salt intake and hypertension and/or salt-sensitive genes.

AB - We examined the interactions between lifestyle and polymorphisms of salt-sensitive genes and their effects on hypertension in a general Japanese sample (The Shigaraki Study). The study group consisted of 2,902 subjects who underwent a medical examination in 1999 in Shigaraki, a suburban area in Shiga. Among 1,647 subjects not receiving antihypertensive medication, in a combined analysis of angiotensinogen (AGT) and adducin (ADD1) polymorphisms, double homozygosity of 235Trp or 460Trp was not found to be associated with hypertension. A multiple logistic regression analysis showed that age (odds ratio [OR]: 1.07, 95% confidence interval [95% CI]: 1.06-1.08), body mass index (BMI) (OR: 1.18, 95% CI: 1.13-1.23), alcohol consumption (OR: 1.39, 95% CI: 1.16-1.66), family history of hypertension (OR: 1.57, 95% CI: 1.18-2.07), and combined AGT M235T Thr/Thr and ADD1 Trp/Trp polymorphisms (OR: 1.37, 95% CI: 1.03-1.82) were associated with hypertension. However, there was no interaction between eating salty food and combined AGT and ADD1 polymorphisms. Furthermore, eating salty food was not associated with hypertension in a multivariate analysis. Therefore, a combination of the AGT and ADD1 polymorphisms appears to be associated with hypertension. However, a simple questionnaire regarding salt intake was not sufficient to confirm the relationship between salt intake and hypertension and/or salt-sensitive genes.

KW - Adducin Gly460Trp polymorphism

KW - Angiotensinogen M235T polymorphism

KW - Hypertension

KW - Lifestyle

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