Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

Masayuki Shiraki, Tetsuyo Odajima, Tatsuru Ikeda, Aya Sasaki, Masaaki Satoh, Akira Yamaguchi, Makoto Noguchi, Itaru Nagai, Hiroyoshi Hiratsuka

研究成果: Article査読

45 被引用数 (Scopus)

抄録

p53, cyclin D1 and epidermal growth factor receptor (EGFR) are molecular markers that regulate the cell cycle or cell growth and play important roles in tumor development and progression. In this study, we examined the impact of immunohistochemical expression of these markers on tumor progression in 140 oral cancers. p53, cyclin D1 and EGFR were expressed in 64 cases (46%), 54 cases (39%) and 54 cases (39%), respectively, but there was no inter-relationship between any two of these markers. In the association of these markers with clinicopathological features, EGFR expression alone was significantly associated with poor differentiation (P=0.0008) and invasive growth pattern (P=0.0003). Any of these markers, including EGFR, had no significant impact on survival. Coexpression of all these markers, however, was significantly associated with invasive growth pattern (P=0.0149) and shortened survival (P=0.0181), and was a significant and independent unfavorable prognostic factor (P=0.0002), along with tumor size (P=0.0040), nodal metastasis (P=0.0137) and growth pattern (P=0.0017) in a multivariate analysis. Simultaneous coexpression of these markers in oral cancers might prove to be a useful indicator for identification of low- or high-risk patients.

本文言語English
ページ(範囲)1482-1489
ページ数8
ジャーナルModern Pathology
18
11
DOI
出版ステータスPublished - 2005 11

ASJC Scopus subject areas

  • 病理学および法医学

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