Common epitopes on the SS-B/La proteins of 41 and 29 kD recognized by human autoantibodies

T. Okano, M. Akizuki, H. Yamagata, Y. Ohsone, M. Hirakata, M. Satoh, M. Homma

研究成果: Article

抜粋

The calf thymus SS-B/La antigen precipitated by specific antibodies or purified by affinity chromatography has two major antigenic proteins. The proteins of 41 and 29 kD were found whether whole calf thymus extract (CTE) or the 60-80% saturated ammonium sulfate fraction of CTE were used as a source of SS-B/La. Both proteins were shown to react with human autoantibodies to SS-B/La by immunoblotting. Purified anti-41 and 29 kD SS-B/La antibodies reacted with both 29 and 41 kD proteins in immunoblotting. In agar diffusion, purified anti-41 and 29 kD SS-B/La antibodies and anti-SS-B/La antibodies in the original serum showed a reaction of identity. Both anti-41 and 29 kD protein antibodies showed three immunofluorescent staining patterns on rat liver cells: speckled; nucleolar and speckled associated with disperse cytoplasmic. These results indicate that the common antigenic determinants present on the 41 and 29 kD SS-B/La proteins are recognized by human autoantibodies to the SS-B/La antigen produced in connective tissue diseases.

元の言語English
ページ(範囲)1-12
ページ数12
ジャーナルJapanese Journal of Rheumatology
2
発行部数1
出版物ステータスPublished - 1989 1 1
外部発表Yes

ASJC Scopus subject areas

  • Rheumatology

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  • これを引用

    Okano, T., Akizuki, M., Yamagata, H., Ohsone, Y., Hirakata, M., Satoh, M., & Homma, M. (1989). Common epitopes on the SS-B/La proteins of 41 and 29 kD recognized by human autoantibodies. Japanese Journal of Rheumatology, 2(1), 1-12.