Common marmoset as a new model animal for neuroscience research and genome editing technology

Noriyuki Kishi, Kenya Sato, Erika Sasaki, Hideyuki Okano

研究成果: Review article査読

131 被引用数 (Scopus)

抄録

The common marmoset (Callithrix jacchus) is a small New World primate; it originally comes from the Atlantic coastal forests in northeastern Brazil. It has been attracting much attention in the biomedical research field because of its size, availability, and unique biological characteristics. Its endocrinological and behavioral similarity to humans, comparative ease in handling, and high reproductive efficiency are very advantageous for neuroscience research. Recently, we developed transgenic common marmosets with germline transmission, and this technological breakthrough provides a potential paradigm shift by enabling researchers to investigate complex biological phenomena using genetically-modified non-human primates. In this review, we summarize recent progress in marmoset research, and also discuss a potential application of genome editing tools that should be useful toward the generation of knock-out/knock-in marmoset models.

本文言語English
ページ(範囲)53-62
ページ数10
ジャーナルDevelopment Growth and Differentiation
56
1
DOI
出版ステータスPublished - 2014 1月 1

ASJC Scopus subject areas

  • 発生生物学
  • 細胞生物学

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