Comparative Pharmacokinetics of Cefazolin in Awake and Urethane-Anesthetized Rats

Tetsuya Terasaki, Akira Tsuji, Emi Nakashima, Kazunori Nishide, Charles H. Nightingale, Tsukinaka Yamana

研究成果: Article査読

6 被引用数 (Scopus)

抄録

The influence of urethane and pentobarbital anesthesia on the pharmacokinetics of cefazolin has been investigated in rats. No significant difference of total body clearance or distribution volume was observed between urethane-anesthetized and non-anesthetized rats. There was also no significant difference in plasma concentratiOn of cefazolin at the terminal phase between urethane- pentobarbital-anesthetized and non-anesthetized rats. Good coincidence was demonstrated between the observed tissue-to-plasma partition coefficient, Kp of non-anesthetized rats and the predicted Kpvalue based on the previously proposed model. Hence, it is considered that there is no significant influence of urethane or pentobarbital anesthesia on the distribution and elimination of cefazolin. The proposed physiological model could be useful to predict the distribution of cefazolin in non-anesthetized rats.

本文言語English
ページ(範囲)2153-2154
ページ数2
ジャーナルChemical and Pharmaceutical Bulletin
33
5
DOI
出版ステータスPublished - 1985

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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