Comparative studies of dialyzability of levofloxacin and amlodipine using in vitro dialysis system with three different types of dialyzers

Mayumi Mochizuki, Rieko Yuda, Fumi Amano, Yuki Nakajima, Shin Ichi Yamagata, Shigeto Oda, Shinji Yamane, Masayuki Ishii, Shiro Ueda

研究成果: Article査読

2 被引用数 (Scopus)

抄録

In the pharmacotherapy of patients receiving hemodialysis, the possible exclusion of an administered drug by hemodialysis should be recognized. The present study was undertaken to predict dialyzability of a drug during hemodialysis using an in vitro dialysis system with three different dialyzers made from high performance membrane. Levofloxacin having relatively low binding-affinity to plasma protein was removed ideally during in vitro dialysis. Amlodipine was also eliminated from the blood, although it is generally believed that such drugs with high binding affinity to plasma protein are removed less efficiently, Examination of the adsorption rate and clearance of the drug revealed that disappearance of amlodipine was due to its adsorption to dialysis membrane and its circuit. Thus, drugs with high protein binding-affinity may possibly be removed by dialyzers with high performance membrane.

本文言語English
ページ(範囲)271-275
ページ数5
ジャーナルJournal of Health Science
45
5
DOI
出版ステータスPublished - 1999 1月 1

ASJC Scopus subject areas

  • 毒物学
  • 健康、毒物学および変異誘発

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