Comparison of Cord Blood Transplantation with Unrelated Bone Marrow Transplantation in Patients Older than Fifty Years

Masatsugu Tanaka, Koichi Miyamura, Seitaro Terakura, Kiyotoshi Imai, Naoyuki Uchida, Hiroatsu Ago, Toru Sakura, Tetsuya Eto, Kazuteru Ohashi, Takahiro Fukuda, Shuichi Taniguchi, Shinichiro Mori, Tokiko Nagamura-Inoue, Yoshiko Atsuta, Shin ichiro Okamoto

研究成果: Article査読

14 被引用数 (Scopus)

抄録

We retrospectively compared the transplantation outcomes for patients 50 years or older who received umbilical cord blood transplantation (UCBT) with those who received unrelated bone marrow transplantation (UBMT) for hematologic malignancies. A total of 1377 patients who underwent transplantation between 2000 and 2009 were included: 516 received 8/8 HLA allele-matched UBMT, 295 received 7/8 HLA allele-matched UBMT, and 566 received 4/6 to 6/6 HLA-matched UCBT. Adjusted overall survival (OS) was significantly lower in those who underwent UCBT than those who underwent 8/8 HLA-matched UBMT but was similar to that of 7/8 HLA-matched UBMT (the 2-year OS after 8/8 HLA-matched UBMT, 7/8 HLA-matched UBMT, and UCBT were 49% [95% confidence interval (CI), 45% to 55%], 38% [95% CI, 32% to 45%], and 39% [95% CI, 34% to 43%], respectively). However, adjusted OS was similar between 8/8 HLA-matched UBMT and UCBT receiving ≥.84× 105 CD34+ cells/kg among those with acute myeloid leukemia and those with acute lymphoblastic leukemia (the 2-year OS was 49% [95% CI, 43% to 55%], and 49% [95% CI, 41% to 58%], respectively). These data suggest that UCB is a reasonable alternative donor/stem cell source for elderly patients with similar outcomes compared with UBM from 8/8 HLA-matched unrelated donors when the graft containing ≥.84× 105 CD34+ cells/kg is available.

本文言語English
ページ(範囲)517-525
ページ数9
ジャーナルBiology of Blood and Marrow Transplantation
21
3
DOI
出版ステータスPublished - 2015 3月 1
外部発表はい

ASJC Scopus subject areas

  • 血液学
  • 移植

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