Comparison of temporal response to cerebral blood flow measured by laser speckle flowgraphy and laser Doppler flowmetry

Masashi Kusano, Haruka Nakayama, Hiroyuki Takuwa, Kazuto Masamoto, Iwao Kanno, Eiji Okada

    研究成果: Conference contribution

    1 被引用数 (Scopus)

    抄録

    Cerebral blood flow (CBF) change of mice during whisker stimulation is measured by laser speckle flowgraphy (LSFG) and laser Doppler flowmetry (LDF). Laser speckle flowgraphy (LSFG) has been used to obtain the two-dimensional distribution of the blood flow in tissue as well as scanning laser Doppler flowmetry (LDF). There are several parameters of LSFG to obtain the blood flow maps and the distribution change of blood flow. In this study, we calculate four parameters from the speckle pattern to measure CBF in awake mice. The temporal resolution of LSFG is likely to be less than that of LDF. The temporal changes in CBF obtained from the four parameters calculated from the speckle pattern detected by a common CCD camera are compared with those measured by LDF. The time courses of CBF change measured by LSFG highly correlate with those by LDF. The results indicate that the temporal response of LSFG is sufficient to measure CBF change evoked by brain activations.

    本文言語English
    ホスト出版物のタイトルDiffuse Optical Imaging III
    DOI
    出版ステータスPublished - 2011 7 28
    イベントDiffuse Optical Imaging III - Munich, Germany
    継続期間: 2011 5 222011 5 24

    出版物シリーズ

    名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
    8088
    ISSN(印刷版)1605-7422

    Other

    OtherDiffuse Optical Imaging III
    CountryGermany
    CityMunich
    Period11/5/2211/5/24

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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