Comparison of the inhibitory effects of cilostazol, acetylsalicylic acid and ticlopidine on platelet functions ex vivo. Randomized, double-blind cross-over study

Y. Ikeda, M. Kikuchi, H. Murakami, K. Satoh, M. Murata, K. Watanabe, Y. Ando

研究成果: Article

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A randomized double-blind cross-over study was conducted to determine the inhibitory effects of acetylsalicylic acid (ASA), ticlopidine (TP) and cilostazol (OPC-13013; in the following briefly called CS), a new antithrombotic agent on platelet functions ex vivo. Nine patients with cerebral thrombosis were enrolled in this study. Patients were given each of the three drugs for one week in a complete cross-over design according to a randomization schedule, followed by a wash-out period with a placebo for one week. It was found that CS and TP significantly inhibited platelet aggregation induced by ADP. Collagen- and arachidonic acid-induced platelet aggregation was all inhibited by CS, TP and ASA. Duncan's multiple range test to compare the anti-platelet effects of the three drugs revealed that: CS > ASA and TP > ASA in inhibiting ADP-induced platelet aggregation and CS > TP and ASA > TP in inhibiting arachidonic acid-induced platelet aggregation. These results may suggest that CS is superior to ASA and TP in inhibiting platelet aggregation ex vivo.

元の言語English
ページ(範囲)563-566
ページ数4
ジャーナルArzneimittel-Forschung/Drug Research
37
発行部数5
出版物ステータスPublished - 1987
外部発表Yes

ASJC Scopus subject areas

  • Drug Discovery

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