Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

Kazuhiko Nakamura, Yu Tachikawa, Makoto Kitamura, Osamu Ohno, Masami Suganuma, Daisuke Uemura

研究成果: Article査読

29 被引用数 (Scopus)

抄録

The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.

本文言語English
ページ(範囲)2058-2060
ページ数3
ジャーナルOrganic and Biomolecular Chemistry
6
12
DOI
出版ステータスPublished - 2008 6月 17

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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