抄録
The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 2058-2060 |
| ページ数 | 3 |
| ジャーナル | Organic and Biomolecular Chemistry |
| 巻 | 6 |
| 号 | 12 |
| DOI | |
| 出版ステータス | Published - 2008 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学
