Computational analysis of associations between alternative splicing and histone modifications

Yuki Shindo, Tadasu Nozaki, Rintaro Saito, Masaru Tomita

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Pre-mRNA splicing is a complex process involving combinatorial effects of cis- and trans-elements. Here, we focused on histone modifications as typical trans-regulatory elements and performed systematic analyses of associations between splicing patterns and histone modifications by using publicly available ChIP-Seq, mRNA-Seq, and exon-array data obtained in two human cell lines. We found that several types of histone modifications including H3K36me3 were associated with the inclusion or exclusion of alternative exons. Furthermore, we observed that the levels of H3K36me3 and H3K79me1 in the cell lines were well correlated with the differences in alternative splicing patterns between the cell lines.

本文言語English
ページ(範囲)516-521
ページ数6
ジャーナルFEBS Letters
587
5
DOI
出版ステータスPublished - 2013 3月 1

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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