Computational analysis of microRNA-mediated antiviral defense in humans

Yuka Watanabe, Atsuko Kishi, Nozomu Yachie, Akio Kanai, Masaru Tomita

研究成果: Article査読

37 被引用数 (Scopus)

抄録

Recent studies have proposed the interesting perspective that viral gene expression is downregulated by host microRNAs (miRNAs), small non-coding RNAs well known as post-transcriptional gene regulators. We computationally predicted human miRNA target sites within 228 human-infecting and 348 invertebrate-infecting virus genomes, and we observed that human-infecting viruses were more likely than invertebrate-infecting ones to be targeted by human miRNAs. We listed 62 possible human miRNA-targeted viruses from 6 families, most of which consisted of single-stranded RNA viruses. These results suggest that miRNAs extensively mediate antiviral defenses in humans.

本文言語English
ページ(範囲)4603-4610
ページ数8
ジャーナルFEBS Letters
581
24
DOI
出版ステータスPublished - 2007 10月 2

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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