Computational analysis suggests a highly bendable, fragile structure for nucleosomal DNA

Tadasu Nozaki, Nozomu Yachie, Ryu Ogawa, Rintaro Saito, Masaru Tomita

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Eukaryotic chromosomal DNA coils around histones to form nucleosomes. Although histone affinity for DNA depends on DNA sequence patterns, how nucleosome positioning is determined by them remains unknown. Here, we show relationships between nucleosome positioning and two structural characteristics of DNA conferred by DNA sequence. Analysis of bendability and hydroxyl radical cleavage intensity of nucleosomal DNA sequences indicated that nucleosomal DNA is bendable and fragile and that nucleosome positional stability was correlated with characteristics of DNA. This result explains how histone positioning is partially determined by nucleosomal DNA structure, illuminating the optimization of chromosomal DNA packaging that controls cellular dynamics.

本文言語English
ページ(範囲)10-14
ページ数5
ジャーナルGene
476
1-2
DOI
出版ステータスPublished - 2011 5 1

ASJC Scopus subject areas

  • 遺伝学

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