Computational assessment of insulin secretion and insulin sensitivity from 2-h oral glucose tolerance tests for clinical use for type 2 diabetes

Masayoshi Seike, Takeo Saitou, Yasuhiro Kouchi, Takeshi Ohara, Munehide Matsuhisa, Kazuhiko Sakaguchi, Koji Tomita, Keisuke Kosugi, Atsunori Kashiwagi, Masato Kasuga, Masaru Tomita, Yasuhiro Naito, Hiromu Nakajima

研究成果: Article査読

5 被引用数 (Scopus)

抄録

In type 2 diabetes mellitus, glucose homeostasis is tightly maintained through insulin secretion and insulin sensitivity. Therefore, finding an accurate method to assess insulin secretion and sensitivity using clinically available data would enhance the quality of diabetic medical care. In an effort to find such a method, we developed a computational approach to derive indices of these factors using a 2-h oral glucose tolerance test (OGTT). To evaluate our method, clinical data from subjects who received an OGTT and a glucose clamp test were examined. Our insulin secretion index was significantly correlated with an analogous index obtained from a hyperglycemic clamp test (r = 0.90, n = 46, p < 0.001). Our insulin sensitivity index sensitivity was also significantly correlated with an analogous index obtained from a hyperinsulinemic-euglycemic clamp test (r = 0.56, n = 79, p < 0.001). These results suggest that our method can potentially provide an accurate and convenient tool toward improving the management of diabetes in clinical practice by assessing insulin secretion and insulin sensitivity.

本文言語English
ページ(範囲)321-330
ページ数10
ジャーナルJournal of Physiological Sciences
61
4
DOI
出版ステータスPublished - 2011 7月

ASJC Scopus subject areas

  • 生理学

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