Computational model-based probabilistic analysis of in vivo material properties for ligament stiffness using the laxity test and computed tomography

Kyoung Tak Kang, Sung Hwan Kim, Juhyun Son, Young Han Lee, Heoung Jae Chun

研究成果: Article査読

34 被引用数 (Scopus)

抄録

The objective of this paper was to evaluate in vivo material properties in order to address technical aspects of computational modeling of ligaments in the tibiofemoral joint using a probabilistic method. The laxity test was applied to the anterior-posterior drawer under 30° and 90° of flexion with a series of stress radiographs, a Telos device, and computed tomography. Ligament stiffness was investigated using sensitivity analysis based on the Monte-Carlo method with a subject-specific finite element model generated from in vivo computed tomography and magnetic resonance imaging data, subjected to laxity test conditions. The material properties of ligament stiffness and initial ligament strain in a subject-specific finite element model were optimized to minimize the differences between the movements of the tibia and femur in the finite element model and the computed tomography images in the laxity test. The posterior cruciate ligament was the most significant factor in flexion and posterior drawer, while the anterior cruciate ligament primarily was the most significant factor for the anterior drawer. The optimized material properties model predictions in simulation and the laxity test were more accurate than predictions based on the initial material properties in subject-specific computed tomography measurement. Thus, this study establishes a standard for future designs in allograft, xenograft, and artificial ligaments for anterior cruciate ligament and posterior cruciate ligament injuries.

本文言語English
論文番号183
ジャーナルJournal of Materials Science: Materials in Medicine
27
12
DOI
出版ステータスPublished - 2016 12 1
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • バイオエンジニアリング
  • 生体材料
  • 生体医工学

フィンガープリント

「Computational model-based probabilistic analysis of in vivo material properties for ligament stiffness using the laxity test and computed tomography」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル