Conjunctival epithelium expression of HLA-DR in dry eye patients

Kazuo Tsubota, Tsutomu Fujihara, Keiko Saito, Tsutomu Takeuchi

研究成果: Article査読

89 被引用数 (Scopus)

抄録

Purpose: To compare conjunctival epithelium expression of HLA-DR and ICAM-1 with tear dynamics and ocular surface parameters. Methods: Brush cytology and flow cytometry were used to quantitatively analyze HLA-DR and ICAM-1 expression in 28 dry eye patients. Results: HLA-DR was expressed in 66% of the conjunctival cells of dry eye patients. This expression correlates with that of ICAM-1, as well as with the Schirmer test results (p<0.05). Conclusion: This study confirmed that dry eye consists not only of ocular surface desiccation, but also of upregulation of the HLA-DR and ICAM-1 molecule in the conjunctival epithelium, possibly resulting in increased inflammation.

本文言語English
ページ(範囲)16-19
ページ数4
ジャーナルOphthalmologica
213
1
DOI
出版ステータスPublished - 1999

ASJC Scopus subject areas

  • 眼科学
  • 感覚系

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