Conquering amide planarity: Structural distortion and its hidden reactivity

Shinya Adachi, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Review article査読

36 被引用数 (Scopus)

抄録

Amides are generally considered as a low-reactive chemical entity among the carbonyl group, and therefore fewer opportunities to be involved in catalytic transformations as substrates. The origin of the stable nature of amides is resonance stabilization in the planar structure, which has drawn considerable attention from organic and physical chemists, leading to the discovery of distorted amides that exhibit a substantially reactive nature. Recent focus in this field is on the catalytic transformation of designed amides with moderate distortion or reduced resonance stabilization. This digest reviews the brief history of the quest for highly distorted amides and introduces a collection of recent studies on catalytic transformations of designed amides.

本文言語English
ページ(範囲)1147-1158
ページ数12
ジャーナルTetrahedron Letters
59
13
DOI
出版ステータスPublished - 2018 3月 28
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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