Consequence of the loss of Sox2 in the developing brain of the mouse

Satoru Miyagi, Shinji Masui, Hitoshi Niwa, Tetsuichiro Saito, Takuya Shimazaki, Hideyuki Okano, Masazumi Nishimoto, Masami Muramatsu, Atsushi Iwama, Akihiko Okuda

研究成果: Article査読

69 被引用数 (Scopus)

抄録

The transcription factor Sox2 is expressed at high levels in neural stem and progenitor cells. Here, we inactivated Sox2 specifically in the developing brain by using Cre-loxP system. Although mutant animals did not survive after birth, analysis of late gestation embryos revealed that loss of Sox2 causes enlargement of the lateral ventricles and a decrease in the number of neurosphere-forming cells. However, although their neurogenic potential is attenuated, Sox2-deficient neural stem cells retain their multipotency and self-renewal capacity. We found that expression level of Sox3 is elevated in Sox2 null developing brain, probably mitigating the effects of loss of Sox2.

本文言語English
ページ(範囲)2811-2815
ページ数5
ジャーナルFEBS Letters
582
18
DOI
出版ステータスPublished - 2008 8 6

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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