Construction of a Meroterpenoid-Like Compounds Library Based on Diversity-Enhanced Extracts

Haruhisa Kikuchi, Kosuke Kawai, Yota Nakashiro, Takayuki Yonezawa, Kumi Kawaji, Eiichi N. Kodama, Yoshiteru Oshima

研究成果: Article査読

9 被引用数 (Scopus)

抄録

The structural diversity of natural products and their derivatives have long contributed to the development of new drugs. However, the difficulty in obtaining compounds bearing skeletally novel structures has recently led to a decline of pharmaceutical research into natural products. This paper reports the construction of a meroterpenoid-like library containing 25 compounds with diverse molecular scaffolds obtained from diversity-enhanced extracts. This method constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Extensive pharmacological screening of the library revealed promising compounds for anti-osteoporotic and anti-lymphoma/leukemia drugs. This result indicates that the use of diversity-enhanced extracts is an effective methodology for producing chemical libraries for the purpose of drug discovery.

本文言語English
ページ(範囲)1106-1112
ページ数7
ジャーナルChemistry - A European Journal
25
4
DOI
出版ステータスPublished - 2019 1月 18
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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