@article{a8e01448e6c7443bb59ebdf0c958c3d8,
title = "Construction of a Meroterpenoid-Like Compounds Library Based on Diversity-Enhanced Extracts",
abstract = "The structural diversity of natural products and their derivatives have long contributed to the development of new drugs. However, the difficulty in obtaining compounds bearing skeletally novel structures has recently led to a decline of pharmaceutical research into natural products. This paper reports the construction of a meroterpenoid-like library containing 25 compounds with diverse molecular scaffolds obtained from diversity-enhanced extracts. This method constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Extensive pharmacological screening of the library revealed promising compounds for anti-osteoporotic and anti-lymphoma/leukemia drugs. This result indicates that the use of diversity-enhanced extracts is an effective methodology for producing chemical libraries for the purpose of drug discovery.",
keywords = "chemical library, diversity-enhanced extracts, drug discovery, natural products, terpenoids",
author = "Haruhisa Kikuchi and Kosuke Kawai and Yota Nakashiro and Takayuki Yonezawa and Kumi Kawaji and Kodama, {Eiichi N.} and Yoshiteru Oshima",
note = "Funding Information: This work was supported in part by the Grants-in-Aid for Scientific Research (no. 16H03279 and 16H05346) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan; the Platform Project for Supporting in Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)), and Practical Research for Innovative Cancer Control from AMED under Grant Numbers JP18am0101095/ JP18am0101100, and JP17ck0106282/ JP18ck0106282, respectively; the Shorai Foundation for Science and Technology; Kobayashi International Scholarship Foundation; the Takeda Science Foundation; Suzuken Memorial Foundation and the Uehara Memorial Foundation. Funding Information: This work was supported in part by the Grants-in-Aid for Scientific Research (no. 16H03279 and 16H05346) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan; the Platform Project for Supporting in Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)), and Practical Research for Innovative Cancer Control from AMED under Grant Numbers JP18am0101095/ JP18am0101100, and JP17ck0106282/ JP18ck0106282, respectively; the Shorai Foundation for Science and Technology; Kobayashi International Scholarship Foundation; the Takeda Science Foundation; Su-zuken Memorial Foundation and the Uehara Memorial Foundation. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = jan,
day = "18",
doi = "10.1002/chem.201805417",
language = "English",
volume = "25",
pages = "1106--1112",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "4",
}