Construction of a series of mutants lacking all of the four major mex operons for multidrug efflux pumps or possessing each one of the operons from Pseudomonas aeruginosa PAO1: MexCD-OprJ is an inducible pump

Yuji Morita, Yukiko Komori, Takehiko Mima, Teruo Kuroda, Tohru Mizushima, Tomofusa Tsuchiya

研究成果: Article

67 引用 (Scopus)

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We constructed a series of deletion mutants lacking all of the four major mex operons for Mex multidrug efflux pumps or possessing each one of the operons from Pseudomonas aeruginosa PAO1. The drug specificity of MexAB-OprM, MexXY-OprM and MexCD-OprJ was investigated. Surprisingly, we found that the MexCD-OprJ was an inducible pump, inducers of which were tetraphenylphosphonium chloride, ethidium bromide, rhodamine 6G and acriflavine. Fluoroquinolones, chloramphenicol, erythromycin and tetracycline were not inducers although they were substrates of MexCD-OprJ.

元の言語English
ページ(範囲)139-143
ページ数5
ジャーナルFEMS microbiology letters
202
発行部数1
DOI
出版物ステータスPublished - 2001 8 7

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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