Construction of epidithiodioxopiperazines by directed oxidation of hydroxyproline-derived dioxopiperazines

Larry E. Overman, Takaaki Sato

研究成果: Article査読

45 被引用数 (Scopus)

抄録

(Chemical Equation Presented) Functionalization of the angular methine carbon of hydroxyproline-derived dioxopiperazines by a radical-promoted C-H bond oxidation, which is directed by a proximal (bromomethyl)silyl group, is described. This regioselective oxidation is the key step in a new synthesis of epidithiodioxopiperazines.

本文言語English
ページ(範囲)5267-5270
ページ数4
ジャーナルOrganic Letters
9
25
DOI
出版ステータスPublished - 2007 12 6
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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