Continuous measurement of blood oxygen pressure using a fiber optic sensor based on phosphorescence quenching

Kentaro Hase, Shuhei Sakai, Kosuke Tsukada, Eiichi Sekizuka, Chikara Oshio, Haruyuki Minamitani

研究成果: Conference article査読

抄録

Measuring oxygen pressure within an artery is essential for providing information on blood perfusion. Optic-sensor is particularly well suited for oxygen pressure measurement because electrolytic or magnetic changes of the environment do not affect the measurement. We developed a fiber optical sensor based on phosphorescence quenching method. The probe, Pd-meso-tetra(4-carboxyphenyl)porphyrin, was immobilized to the silicone resin membrane, which has high oxygen permeability, and attached to the tip of POF (outer diameter: 500μm). The light source used for exciting the probe was a Nd:YAG-SH pulse laser (532nm) and the phosphorescent emission was detected by a photomultiplier tube. The signal was fitted to a single exponential decay curve to acquire the time constant (life time), thereafter the oxygen pressure was calculated from Stern-Volmer relationship. Effectiveness of the sensor was obtained to measure the dissolved oxygen with high precision (correlation coefficient 0.999) and high response time (about 7sec). In this study, measurement of oxygen pressure was also made in femoral artery of rat by using the developed sensor and it indicated that it was very useful to measure arterial oxygen pressure continuously.

本文言語English
ページ(範囲)1777-1778
ページ数2
ジャーナルAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
2
出版ステータスPublished - 2002
イベントProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
継続期間: 2002 10月 232002 10月 26

ASJC Scopus subject areas

  • 信号処理
  • 生体医工学
  • コンピュータ ビジョンおよびパターン認識
  • 健康情報学

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