Continuous Separation Method with Liquid Particle Extractor: Enantioseparation of Mandelic Acid

Hideyuki Nishizawa, Kayoko Tahara, Aiko Hayashida, Yoshihiro Abe

研究成果: Article

12 引用 (Scopus)

抜粋

Continuous enantioseparation of (±)-mandelic acid was performed by dual-flow countercurrent extraction. The optimum extraction condition was calculated by a semi-empirical computational method. Use of the two-phase system composed of a 0.2 mM copper(II) acetate aqueous solution and butanol containing 10 mM JV-dodecyl-L-proline copper(II) complex as a chiral separator allowed (±)-mandelic acid to be separated continuously. HPLC analysis showed that the-form was extracted into the organic phase and the (+)-form was recovered from the aqueous extract with ee higher than 99.9%, at the stationary state.

元の言語English
ページ(範囲)611-615
ページ数5
ジャーナルanalytical sciences
9
発行部数5
DOI
出版物ステータスPublished - 1993

ASJC Scopus subject areas

  • Analytical Chemistry

フィンガープリント Continuous Separation Method with Liquid Particle Extractor: Enantioseparation of Mandelic Acid' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用