Contribution of a peroxide adduct of copper(II)-peptide complex to modify the secondary structure of albumin

Yoshihiro Ishikawa, Sayo Ito, Satsohi Nishino, Shigeru Ohba, Yuzo Nishida

研究成果: Article査読

15 被引用数 (Scopus)

抄録

We have found that copper(II) compounds containing a peptide group in the chelate exhibit high activity for modification or degradation of albumin in the presence of hydrogen peroxide, whereas no activity was detected for the copper(II) compounds without an amide-group. It is suggested that presence of the amide-group in the ligand may play an important role in the formation of a peroxide adduct and in activation of the peroxide ion, leading to cleavage of the peptide bond of a neighboring protein. It is implied that conversion of normal cellular prion protein PrP(C) into a disease-causing isoform, PrP(Sc) is attributed to the activated peroxide ion coordinated to a copper(II) captured in the NH2-terminal domain of the PrP(C).

本文言語English
ページ(範囲)378-382
ページ数5
ジャーナルZeitschrift fur Naturforschung - Section C Journal of Biosciences
53
5-6
DOI
出版ステータスPublished - 1998

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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