Contribution of developmental changes in energy metabolism to excitation-contraction coupling of a ventricular cell: A simulation study

Hitomi I. Sano, Tamami Toki, Yasuhiro Naito, Masaru Tomita

研究成果: Conference article査読

抄録

In fetal guinea pigs, ventricular cells have higher anaerobic glycolytic capacity and lower mitochondrial enzyme activity. Here, we implemented developmental changes in glycolytic enzyme activity, concentrations of glycogen, and total creatine in late embryonic and adult ventricular cell models. We then simulated the effects of hypoxic conditions on dynamic changes in contractile force and ATP concentration. Our model demonstrates that fetal ventricular cells maintain ATP for longer periods of time than adult ventricular cells. This is consistent with reported dynamics of ventricular cells under hypoxic conditions.

本文言語English
論文番号7042982
ページ(範囲)73-76
ページ数4
ジャーナルComputing in Cardiology
41
January
出版ステータスPublished - 2014 1 1
イベント41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States
継続期間: 2014 9 72014 9 10

ASJC Scopus subject areas

  • コンピュータ サイエンス(全般)
  • 循環器および心血管医学

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