Contribution of dopamine D1 and D2 receptors to amygdala activity in human

Hidehiko Takahashi, Harumasa Takano, Fumitoshi Kodaka, Ryosuke Arakawa, Makiko Yamada, Tatsui Otsuka, Yoshiyuki Hirano, Hideyuki Kikyo, Yoshiro Okubo, Motoichiro Kato, Takayuki Obata, Hiroshi Ito, Tetsuya Suhara

研究成果: Article

30 引用 (Scopus)

抄録

Several animal studies have demonstrated functional roles of dopamine (DA) D1 and D2 receptors in amygdala activity. However, the contribution of DA D1 and D2 receptors to amygdala response induced by affective stimuli in human is unknown. To investigate the contribution of DA receptor subtypes to amygdala reactivity in human, we conducted a multimodal in vivo neuroimaging study in which DA D1 and D2 receptor bindings in the amygdala were measured with positron emission tomography (PET), and amygdala response induced by fearful faces was assessed by functional magnetic resonance imaging (fMRI) in healthy volunteers. We used multimodality voxelwise correlation analysis between fMRI signal and DA receptor binding measured by PET. DA D1 binding in the amygdala was positively correlated with amygdala signal change in response to fearful faces, but DA D2 binding in the amygdala was not related to amygdala signal change. DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective.

元の言語English
ページ(範囲)3043-3047
ページ数5
ジャーナルJournal of Neuroscience
30
発行部数8
DOI
出版物ステータスPublished - 2010 2 24

Fingerprint

Dopamine D1 Receptors
Dopamine D2 Receptors
Amygdala
Human Activities
Dopamine Receptors
Positron-Emission Tomography
Dopamine
Magnetic Resonance Imaging
Neuroimaging
Healthy Volunteers

ASJC Scopus subject areas

  • Neuroscience(all)

これを引用

Takahashi, H., Takano, H., Kodaka, F., Arakawa, R., Yamada, M., Otsuka, T., ... Suhara, T. (2010). Contribution of dopamine D1 and D2 receptors to amygdala activity in human. Journal of Neuroscience, 30(8), 3043-3047. https://doi.org/10.1523/JNEUROSCI.5689-09.2010

Contribution of dopamine D1 and D2 receptors to amygdala activity in human. / Takahashi, Hidehiko; Takano, Harumasa; Kodaka, Fumitoshi; Arakawa, Ryosuke; Yamada, Makiko; Otsuka, Tatsui; Hirano, Yoshiyuki; Kikyo, Hideyuki; Okubo, Yoshiro; Kato, Motoichiro; Obata, Takayuki; Ito, Hiroshi; Suhara, Tetsuya.

:: Journal of Neuroscience, 巻 30, 番号 8, 24.02.2010, p. 3043-3047.

研究成果: Article

Takahashi, H, Takano, H, Kodaka, F, Arakawa, R, Yamada, M, Otsuka, T, Hirano, Y, Kikyo, H, Okubo, Y, Kato, M, Obata, T, Ito, H & Suhara, T 2010, 'Contribution of dopamine D1 and D2 receptors to amygdala activity in human', Journal of Neuroscience, 巻. 30, 番号 8, pp. 3043-3047. https://doi.org/10.1523/JNEUROSCI.5689-09.2010
Takahashi H, Takano H, Kodaka F, Arakawa R, Yamada M, Otsuka T その他. Contribution of dopamine D1 and D2 receptors to amygdala activity in human. Journal of Neuroscience. 2010 2 24;30(8):3043-3047. https://doi.org/10.1523/JNEUROSCI.5689-09.2010
Takahashi, Hidehiko ; Takano, Harumasa ; Kodaka, Fumitoshi ; Arakawa, Ryosuke ; Yamada, Makiko ; Otsuka, Tatsui ; Hirano, Yoshiyuki ; Kikyo, Hideyuki ; Okubo, Yoshiro ; Kato, Motoichiro ; Obata, Takayuki ; Ito, Hiroshi ; Suhara, Tetsuya. / Contribution of dopamine D1 and D2 receptors to amygdala activity in human. :: Journal of Neuroscience. 2010 ; 巻 30, 番号 8. pp. 3043-3047.
@article{2ceb1d50c0f54b96ae949e47798e1cf6,
title = "Contribution of dopamine D1 and D2 receptors to amygdala activity in human",
abstract = "Several animal studies have demonstrated functional roles of dopamine (DA) D1 and D2 receptors in amygdala activity. However, the contribution of DA D1 and D2 receptors to amygdala response induced by affective stimuli in human is unknown. To investigate the contribution of DA receptor subtypes to amygdala reactivity in human, we conducted a multimodal in vivo neuroimaging study in which DA D1 and D2 receptor bindings in the amygdala were measured with positron emission tomography (PET), and amygdala response induced by fearful faces was assessed by functional magnetic resonance imaging (fMRI) in healthy volunteers. We used multimodality voxelwise correlation analysis between fMRI signal and DA receptor binding measured by PET. DA D1 binding in the amygdala was positively correlated with amygdala signal change in response to fearful faces, but DA D2 binding in the amygdala was not related to amygdala signal change. DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective.",
author = "Hidehiko Takahashi and Harumasa Takano and Fumitoshi Kodaka and Ryosuke Arakawa and Makiko Yamada and Tatsui Otsuka and Yoshiyuki Hirano and Hideyuki Kikyo and Yoshiro Okubo and Motoichiro Kato and Takayuki Obata and Hiroshi Ito and Tetsuya Suhara",
year = "2010",
month = "2",
day = "24",
doi = "10.1523/JNEUROSCI.5689-09.2010",
language = "English",
volume = "30",
pages = "3043--3047",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "8",

}

TY - JOUR

T1 - Contribution of dopamine D1 and D2 receptors to amygdala activity in human

AU - Takahashi, Hidehiko

AU - Takano, Harumasa

AU - Kodaka, Fumitoshi

AU - Arakawa, Ryosuke

AU - Yamada, Makiko

AU - Otsuka, Tatsui

AU - Hirano, Yoshiyuki

AU - Kikyo, Hideyuki

AU - Okubo, Yoshiro

AU - Kato, Motoichiro

AU - Obata, Takayuki

AU - Ito, Hiroshi

AU - Suhara, Tetsuya

PY - 2010/2/24

Y1 - 2010/2/24

N2 - Several animal studies have demonstrated functional roles of dopamine (DA) D1 and D2 receptors in amygdala activity. However, the contribution of DA D1 and D2 receptors to amygdala response induced by affective stimuli in human is unknown. To investigate the contribution of DA receptor subtypes to amygdala reactivity in human, we conducted a multimodal in vivo neuroimaging study in which DA D1 and D2 receptor bindings in the amygdala were measured with positron emission tomography (PET), and amygdala response induced by fearful faces was assessed by functional magnetic resonance imaging (fMRI) in healthy volunteers. We used multimodality voxelwise correlation analysis between fMRI signal and DA receptor binding measured by PET. DA D1 binding in the amygdala was positively correlated with amygdala signal change in response to fearful faces, but DA D2 binding in the amygdala was not related to amygdala signal change. DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective.

AB - Several animal studies have demonstrated functional roles of dopamine (DA) D1 and D2 receptors in amygdala activity. However, the contribution of DA D1 and D2 receptors to amygdala response induced by affective stimuli in human is unknown. To investigate the contribution of DA receptor subtypes to amygdala reactivity in human, we conducted a multimodal in vivo neuroimaging study in which DA D1 and D2 receptor bindings in the amygdala were measured with positron emission tomography (PET), and amygdala response induced by fearful faces was assessed by functional magnetic resonance imaging (fMRI) in healthy volunteers. We used multimodality voxelwise correlation analysis between fMRI signal and DA receptor binding measured by PET. DA D1 binding in the amygdala was positively correlated with amygdala signal change in response to fearful faces, but DA D2 binding in the amygdala was not related to amygdala signal change. DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective.

UR - http://www.scopus.com/inward/record.url?scp=77649087471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649087471&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.5689-09.2010

DO - 10.1523/JNEUROSCI.5689-09.2010

M3 - Article

C2 - 20181600

AN - SCOPUS:77649087471

VL - 30

SP - 3043

EP - 3047

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 8

ER -