Control mechanism of JAK/STAT signal transduction pathway

Satoshi Yamada, Satoru Shiono, Akiko Joo, Akihiko Yoshimura

研究成果: Article査読

157 被引用数 (Scopus)

抄録

Suppressor of cytokine signaling-1 (SOCS1) was identified as the negative regulator of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signal transduction pathway. However, the kinetics and control mechanism of the pathway have not yet been fully understood. We have developed the computer simulation of the JAK/STAT pathway. Without nuclear phosphatase, SOCS1's binding to JAK did not cause the decrease in nuclear phosphorylated STAT1. However, without SH2 domain-containing tyrosine phosphatase 2 (SHP-2) or cytoplasmic phosphatase, it did. So nuclear phosphatase is considered to be the most important in this system. By changing parameters of the model, dynamical characteristics and control mechanism were investigated.

本文言語English
ページ(範囲)190-196
ページ数7
ジャーナルFEBS Letters
534
1-3
DOI
出版ステータスPublished - 2003 1月 16
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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