Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity

Federico Bolognani, Daniel C. Tanner, Sayuri Nixon, Hirotaka J. Okano, Hideyuki Okano, Nora I. Perrone-Bizzozero

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Previous work from our laboratory demonstrated that the RNA-binding protein HuD binds to and stabilizes the GAP-43 mRNA. In this study, we characterized the expression of HuD and GAP-43 mRNA in the hippocampus during two forms of neuronal plasticity. During post-natal development, maximal expression of both molecules was found at P5 and their levels steadily decreased thereafter. At P5, HuD was also present in the subventricular zone, where it co-localized with doublecortin. In the adult hippocampus, the basal levels of HuD and GAP-43 were lower than during development but were significantly increased in the dentate gyrus after seizures. The function of HuD in GAP-43 gene expression was confirmed using HuD-KO mice, in which the GAP-43 mRNA was significantly less stable than in wild type mice. Altogether, these results demonstrate that HuD plays a role in the post-transcriptional control of GAP-43 mRNA in dentate granule cells during developmental and adult plasticity.

本文言語English
ページ(範囲)2142-2151
ページ数10
ジャーナルNeurochemical Research
32
12
DOI
出版ステータスPublished - 2007 12

ASJC Scopus subject areas

  • 生化学
  • 細胞および分子神経科学

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