Copper-mediated peptide arylation selective for the N-terminus

Mary K. Miller, Haopei Wang, Kengo Hanaya, Olivia Zhang, Alex Berlaga, Zachary T. Ball

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Polypeptides present remarkable selectivity challenges for chemical methods. Amino groups are ubiquitous in polypeptide structure, yet few paradigms exist for reactivity and selectivity in arylation of amine groups. This communication describes the utilization of boronic acid reagents bearing certaino-electron withdrawing groups for copper-mediated amine arylation of the N-terminus under mild conditions and primarily aqueous solvent. The method adds to the toolkit of boronic acid reagents for polypeptide modification under mild conditions in water that shows complete selectivity for the N-terminus in the presence of lysine side chains.

本文言語English
ページ(範囲)10501-10505
ページ数5
ジャーナルChemical Science
11
38
DOI
出版ステータスPublished - 2020 10 14
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)

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