Copper(II)-catalyzed oxidation of d-α-tocopherol by oxygen in aqueous solution

Yoshiko Nagata, Chie Miyamoto, Yoshikazu Matsushima, Shigenobu Matsumoto

研究成果: Article査読

8 被引用数 (Scopus)

抄録

α-Tocopherol (α-Toc) was solubilized in aqueous solutions using 13 solubilizing agents and the products of oxidation by oxygen in the presence and the absence of Cu(II) were analyzed by HPLC. In the presence of Cu(II), the oxidation was accelerated and 5-formyl-7,8-dimethyltocol and α- tocoquinone were the major oxidation products. Their yields greatly increased in the presence of Cu(II). The yields and the rates of formation of the products were dependent on the properties of solubilizing agents and other conditions as well as the presence of Cu(II) or other metal ions. It is suggested that slight changes in the structure of the solubilizing agents affect the course of the reaction.

本文言語English
ページ(範囲)71-76
ページ数6
ジャーナルChemical and Pharmaceutical Bulletin
48
1
DOI
出版ステータスPublished - 2000 1

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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