Coronary artery disease and a functional polymorphism of hTERT

Yumiko Matsubara, Mitsuru Murata, Kiyoaki Watanabe, Ikuo Saito, Koichi Miyaki, Kazuyuki Omae, Mie Ishikawa, Kenichi Matsushita, Shiro Iwanaga, Satoshi Ogawa, Yasuo Ikeda

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Genetic variation, a -1327T/C polymorphism, of human telomerase reverse transcriptase (hTERT) is associated with leukocyte telomere length in healthy subjects, but clinical significances of this functional polymorphism are not clear. Recently, the relationship between the telomere system and coronary artery disease (CAD) was reported. We investigated the association between the -1327T/C polymorphism and (a) susceptibility to CAD and (b) telomere length in CAD patients. In a case-control study, 104 patients confirmed by coronary angiography and 115 age- and sex-matched controls were enrolled. There was a higher frequency of the -1327C/C genotype in CAD patients (51.9%) compared with controls (36.5%, p = 0.0218). Among the 104 CAD patients, leukocyte telomere length in the -1327C/C genotype (7.62 ± 2.19 kb, mean ± SD) was shorter than that in the -1327T/C and -1327T/T genotypes (8.74 ± 2.92, p = 0.0287). These findings suggest that the -1327C/C genotype is a genetic risk factor for CAD and relates to shorter telomere length among CAD patients.

本文言語English
ページ(範囲)669-672
ページ数4
ジャーナルBiochemical and Biophysical Research Communications
348
2
DOI
出版ステータスPublished - 2006 9 22

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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