Coronary artery disease and a functional polymorphism of hTERT

Yumiko Matsubara, Mitsuru Murata, Kiyoaki Watanabe, Ikuo Saito, Koichi Miyaki, Kazuyuki Omae, Mie Ishikawa, Kenichi Matsushita, Shiro Iwanaga, Satoshi Ogawa, Yasuo Ikeda

研究成果: Article

27 引用 (Scopus)

抄録

Genetic variation, a -1327T/C polymorphism, of human telomerase reverse transcriptase (hTERT) is associated with leukocyte telomere length in healthy subjects, but clinical significances of this functional polymorphism are not clear. Recently, the relationship between the telomere system and coronary artery disease (CAD) was reported. We investigated the association between the -1327T/C polymorphism and (a) susceptibility to CAD and (b) telomere length in CAD patients. In a case-control study, 104 patients confirmed by coronary angiography and 115 age- and sex-matched controls were enrolled. There was a higher frequency of the -1327C/C genotype in CAD patients (51.9%) compared with controls (36.5%, p = 0.0218). Among the 104 CAD patients, leukocyte telomere length in the -1327C/C genotype (7.62 ± 2.19 kb, mean ± SD) was shorter than that in the -1327T/C and -1327T/T genotypes (8.74 ± 2.92, p = 0.0287). These findings suggest that the -1327C/C genotype is a genetic risk factor for CAD and relates to shorter telomere length among CAD patients.

元の言語English
ページ(範囲)669-672
ページ数4
ジャーナルBiochemical and Biophysical Research Communications
348
発行部数2
DOI
出版物ステータスPublished - 2006 9 22

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Polymorphism
Coronary Artery Disease
Telomere
Genotype
Leukocytes
Angiography
human TERT protein
Coronary Angiography
Case-Control Studies
Healthy Volunteers

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

これを引用

Coronary artery disease and a functional polymorphism of hTERT. / Matsubara, Yumiko; Murata, Mitsuru; Watanabe, Kiyoaki; Saito, Ikuo; Miyaki, Koichi; Omae, Kazuyuki; Ishikawa, Mie; Matsushita, Kenichi; Iwanaga, Shiro; Ogawa, Satoshi; Ikeda, Yasuo.

:: Biochemical and Biophysical Research Communications, 巻 348, 番号 2, 22.09.2006, p. 669-672.

研究成果: Article

Matsubara, Y, Murata, M, Watanabe, K, Saito, I, Miyaki, K, Omae, K, Ishikawa, M, Matsushita, K, Iwanaga, S, Ogawa, S & Ikeda, Y 2006, 'Coronary artery disease and a functional polymorphism of hTERT', Biochemical and Biophysical Research Communications, 巻. 348, 番号 2, pp. 669-672. https://doi.org/10.1016/j.bbrc.2006.07.103
Matsubara, Yumiko ; Murata, Mitsuru ; Watanabe, Kiyoaki ; Saito, Ikuo ; Miyaki, Koichi ; Omae, Kazuyuki ; Ishikawa, Mie ; Matsushita, Kenichi ; Iwanaga, Shiro ; Ogawa, Satoshi ; Ikeda, Yasuo. / Coronary artery disease and a functional polymorphism of hTERT. :: Biochemical and Biophysical Research Communications. 2006 ; 巻 348, 番号 2. pp. 669-672.
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abstract = "Genetic variation, a -1327T/C polymorphism, of human telomerase reverse transcriptase (hTERT) is associated with leukocyte telomere length in healthy subjects, but clinical significances of this functional polymorphism are not clear. Recently, the relationship between the telomere system and coronary artery disease (CAD) was reported. We investigated the association between the -1327T/C polymorphism and (a) susceptibility to CAD and (b) telomere length in CAD patients. In a case-control study, 104 patients confirmed by coronary angiography and 115 age- and sex-matched controls were enrolled. There was a higher frequency of the -1327C/C genotype in CAD patients (51.9{\%}) compared with controls (36.5{\%}, p = 0.0218). Among the 104 CAD patients, leukocyte telomere length in the -1327C/C genotype (7.62 ± 2.19 kb, mean ± SD) was shorter than that in the -1327T/C and -1327T/T genotypes (8.74 ± 2.92, p = 0.0287). These findings suggest that the -1327C/C genotype is a genetic risk factor for CAD and relates to shorter telomere length among CAD patients.",
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