TY - JOUR
T1 - Correlates of neurocognitive functions in individuals at ultra-high risk for psychosis - A 6-month follow-up study
AU - Sanada, Kenji
AU - de Azúa, Sonia Ruiz
AU - Nakajima, Shinichiro
AU - Alberich, Susana
AU - Ugarte, Amaia
AU - Zugasti, Jone
AU - Vega, Patricia
AU - Martínez-Cengotitabengoa, Mónica
AU - González-Pinto, Ana
N1 - Funding Information:
This work was supported by “ Health Research Funds from the Spanish Government ” (CIBERSAM; PI15/00793 , PI14/01900 , PI13/02252 , 321212ELBY , 2011111113 , PI11/01977 , PI11/02708 , 20111064 , 2010111170 ). The psychiatric research department in University Hospital of Alava is supported by CIBERSAM founding. These institutions had no further role in the study design, data collection, analysis and interpretation, writing of the report, or in the decision to submit the paper for publication.
Publisher Copyright:
© 2018
PY - 2018/10
Y1 - 2018/10
N2 - Cognitive deficits are evident at the prodromal phase of psychosis. It has been noted that brain-derived neurotrophic factor (BDNF) is correlated with cognition in both preclinical and clinical studies. However, to our knowledge, no study has evaluated blood BDNF levels and their association with cognitive impairment in individuals at ultra-high risk for psychosis (UHR). We included 13 individuals at UHR and 30 healthy controls (HC) matched by sex, age, and educational level. Plasma BDNF levels were measured at baseline and 6 months. Neurocognitive functions (executive functions, speed of processing, verbal learning and memory, working memory) were examined at 6 months. Regression analyses were conducted to examine the relationship between BDNF levels and cognitive performance. BDNF levels were lower in UHR group than in HC group both at baseline and at 6 months (P = 0.001, and P = 0.007, respectively). There were no associations between plasma BDNF levels and all of the cognitive domains in both groups. Our findings showed that peripheral BDNF levels were not related to cognitive deficits in UHR and HC groups while the lower BDNF level in the former persisted up to 6 months. Further research is needed in a large sample.
AB - Cognitive deficits are evident at the prodromal phase of psychosis. It has been noted that brain-derived neurotrophic factor (BDNF) is correlated with cognition in both preclinical and clinical studies. However, to our knowledge, no study has evaluated blood BDNF levels and their association with cognitive impairment in individuals at ultra-high risk for psychosis (UHR). We included 13 individuals at UHR and 30 healthy controls (HC) matched by sex, age, and educational level. Plasma BDNF levels were measured at baseline and 6 months. Neurocognitive functions (executive functions, speed of processing, verbal learning and memory, working memory) were examined at 6 months. Regression analyses were conducted to examine the relationship between BDNF levels and cognitive performance. BDNF levels were lower in UHR group than in HC group both at baseline and at 6 months (P = 0.001, and P = 0.007, respectively). There were no associations between plasma BDNF levels and all of the cognitive domains in both groups. Our findings showed that peripheral BDNF levels were not related to cognitive deficits in UHR and HC groups while the lower BDNF level in the former persisted up to 6 months. Further research is needed in a large sample.
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U2 - 10.1016/j.psychres.2018.06.053
DO - 10.1016/j.psychres.2018.06.053
M3 - Article
C2 - 29986171
AN - SCOPUS:85049308319
SN - 0165-1781
VL - 268
SP - 1
EP - 7
JO - Psychiatry Research
JF - Psychiatry Research
ER -
