Correlation among body composition and metabolic regulation in a male mouse model of cushing’s syndrome

Masaaki Uehara, Hiroki Yamazaki, Noritada Yoshikawa, Akiko Kuribara-Souta, Hirotoshi Tanaka

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Glucocorticoids play a critical role in the regulation of homeostasis, including metabolism. In patients with Cushing’s syndrome, chronic glucocorticoid excess disrupts physiological internal milieu, resulting in central obesity, muscle atrophy, fatty liver, and insulin resistance. However, the relationship among various metabolic effects of glucocorticoids remains unknown. In the present study, we studied a male mouse model of Cushing’ s syndrome and indicated that glucocorticoid excess alters metabolic phenotype and body composition involving possible communication among skeletal muscle, liver, and adipose tissue.

本文言語English
ページ(範囲)21-30
ページ数10
ジャーナルEndocrine journal
67
1
DOI
出版ステータスPublished - 2020
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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