Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products

Yusuke Tanigawara, Kiyoshi Yamaoka, Terumichi Nakagawa, Mutsumi Nakagawa, Toyozo Uno

研究成果: Article査読

16 被引用数 (Scopus)

抄録

The mean in vitro dissolution times {in vitro MDT) of ampicillin products were evaluated from the dissolution curves in distilled water using the USP-XX dissolution apparatus, and were compared with the mean in vivo dissolution times (in vivo MDT) reported previously. In both in vivo and in vitro cases, MDT of the trihydrate capsule was greater than those of the anhydrate capsules. A good linear correlation was observed between in vivo and in vitro MDT (r = 0.999, p <0.001).

本文言語English
ページ(範囲)370-372
ページ数3
ジャーナルJournal of Pharmacobio-Dynamics
5
5
DOI
出版ステータスPublished - 1982
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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