Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products

Yusuke Tanigawara; Kiyoshi Yamaoka; Terumichi Nakagawa; Mutsumi Nakagawa; Toyozo Uno

doi:10.1248/bpb1978.5.370

Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products

Yusuke Tanigawara, Kiyoshi Yamaoka, Terumichi Nakagawa, Mutsumi Nakagawa, Toyozo Uno

研究成果: Article › 査読

2 被引用数 (Scopus)

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The mean in vitro dissolution times {in vitro MDT) of ampicillin products were evaluated from the dissolution curves in distilled water using the USP-XX dissolution apparatus, and were compared with the mean in vivo dissolution times (in vivo MDT) reported previously. In both in vivo and in vitro cases, MDT of the trihydrate capsule was greater than those of the anhydrate capsules. A good linear correlation was observed between in vivo and in vitro MDT (r = 0.999, p <0.001).

本文言語	English
ページ（範囲）	370-372
ページ数	3
ジャーナル	Journal of Pharmacobio-Dynamics
巻	5
号	5
DOI	https://doi.org/10.1248/bpb1978.5.370
出版ステータス	Published - 1982
外部発表	はい

ASJC Scopus subject areas

薬理学

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10.1248/bpb1978.5.370

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title = "Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products",

abstract = "The mean in vitro dissolution times {in vitro MDT) of ampicillin products were evaluated from the dissolution curves in distilled water using the USP-XX dissolution apparatus, and were compared with the mean in vivo dissolution times (in vivo MDT) reported previously. In both in vivo and in vitro cases, MDT of the trihydrate capsule was greater than those of the anhydrate capsules. A good linear correlation was observed between in vivo and in vitro MDT (r = 0.999, p <0.001).",

keywords = "ampicillin, bioavailability, bioequivalence, in vivo-in vitro correlation, mean dissolution time, moments",

author = "Yusuke Tanigawara and Kiyoshi Yamaoka and Terumichi Nakagawa and Mutsumi Nakagawa and Toyozo Uno",

year = "1982",

doi = "10.1248/bpb1978.5.370",

language = "English",

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journal = "Biological and Pharmaceutical Bulletin",

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AU - Tanigawara, Yusuke

AU - Yamaoka, Kiyoshi

AU - Nakagawa, Terumichi

AU - Nakagawa, Mutsumi

AU - Uno, Toyozo

PY - 1982

Y1 - 1982

N2 - The mean in vitro dissolution times {in vitro MDT) of ampicillin products were evaluated from the dissolution curves in distilled water using the USP-XX dissolution apparatus, and were compared with the mean in vivo dissolution times (in vivo MDT) reported previously. In both in vivo and in vitro cases, MDT of the trihydrate capsule was greater than those of the anhydrate capsules. A good linear correlation was observed between in vivo and in vitro MDT (r = 0.999, p <0.001).

AB - The mean in vitro dissolution times {in vitro MDT) of ampicillin products were evaluated from the dissolution curves in distilled water using the USP-XX dissolution apparatus, and were compared with the mean in vivo dissolution times (in vivo MDT) reported previously. In both in vivo and in vitro cases, MDT of the trihydrate capsule was greater than those of the anhydrate capsules. A good linear correlation was observed between in vivo and in vitro MDT (r = 0.999, p <0.001).

KW - ampicillin

KW - bioavailability

KW - bioequivalence

KW - in vivo-in vitro correlation

KW - mean dissolution time

KW - moments

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JO - Biological and Pharmaceutical Bulletin

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Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products

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